Results 101 to 110 of about 4,047,389 (301)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Plant analysis as a tool to determine crop nitrogen status [PDF]
, 2007 An effective plant nutrient management strategy optimises nitrogen (N) use efficiency for minimised environmental impact, while ensuring an optimum N status of the crop for good product quality and maximum growth.
Ekbladh, Göran
core
, 2019 We study the dependency of the concentration on mass and redshift using three large N-body cosmological hydrodynamic simulations carried out by the Magneticum project.
Biviano, Andrea +4 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
SUPPORT DISTRIBUTION TO AGRIBUSINESSES IN KRASNOYARSK KRAI
Наука КрасноярьяThe effectiveness of state support is affected not only by its structure by type, but also by its distribution among producers. In 2022, the 30 largest agribusinesses, receiving 46.3% of the total support, provide 58.3% of tax revenues in the AIC of ...
Sanat K. Seitov
doaj +1 more source
The urine-to-plasma urea concentration ratio is associated with eGFR and eGFR decline over time in a population cohort. [PDF]
Nephrol Dial Transplant, 2023 Petrovic D +9 more
europepmc +1 more source
Anisotropic Electron Spin Lifetime in (In,Ga)As/GaAs (110) Quantum Wells
, 2007 Anisotropic electron spin lifetimes in strained undoped (In,Ga)As/GaAs (110) quantum wells of different width and height are investigated by time-resolved Faraday rotation and time-resolved transmission and are compared to the (001)-orientation. From the
Beschoten, B. +5 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source