Results 111 to 120 of about 4,047,389 (301)

A perspective on the current use of the phase distribution model for predicting milk-to-plasma drug concentration ratio. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2022
Zhang M, Sychterz C, Chang M, Huang L, Schmidt BJ, Gaohua L.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Structure - Conduct - Performance paradigm revisited: an empirical analysis for Vietnamese firms

Journal of International Economics and Management, 2014
The Structure-Conduct-Performance (SCP) paradigm became the dominant framework for empirical work in Industrial Organization starting from the early 1950s.1 There have been a large number of empirical researches in the literature examining the SCP ...
Thuy Anh Tu, Thi Thanh Binh Dinh, Binh Duong Nguyen, Viet Duong Nguyen   +3 more
doaj  

Drain fluid and serum amylase concentration ratio is the most reliable indicator for predicting postoperative pancreatic fistula after distal pancreatectomy. [PDF]

BMC Surg, 2023
Fukada M, Murase K, Higashi T, Yasufuku I, Sato Y, Tajima JY, Kiyama S, Tanaka Y, Okumura N, Takahashi T, Matsuhashi N.   +10 more
europepmc   +1 more source

Influence of magnetic impurities on the heat capacity of nuclear spins

, 1997
It is found that in a wide range of temperatures and magnetic fields even a small concentration of magnetic impurities in a sample leads to a $T^{-1}$ temperature dependence of the nuclear heat capacity.
A. M. Dyugaev, A. M. Dyugaev, J. Winter, M. T. Huiku, P. Fulde, P. J. Hakonen, S. Rehmann, T. Herrmannsdörfer, Yu. N. Ovchinnikov   +8 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio. [PDF]

Biomedicines, 2022
Golikova MV, Alieva KN, Filimonova AV, Ageevets VA, Sulian OS, Avdeeva AA, Sidorenko SV, Zinner SH.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism: a systematic review and meta-analysis. [PDF]

Ann Transl Med, 2022
Gao H, Luo R, Li J, Tian H.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source