Results 101 to 110 of about 10,506,870 (352)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Expansion of Tubular with Elastomers in Multilateral Wells

The Journal of Engineering Research, 2013
The use of solid expandable tubular technology during the last decade has focused on solving many challenges in well drilling and delivery including zonal isolation, deep drilling, conservation of hole sizes, etc.
Md Velden, FKS Al-Jahwari
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Wide alar base: Minimally invasive intraoral interalar suture for enhancing facial aesthetics

Advances in Oral and Maxillofacial Surgery, 2023
Stella Aparecida de Andrade Pinto, José Hyczy Fonseca Junior, Renata Sari Precetti, Danilo Siqueira Pino, Francisco José de Nadai Dias   +4 more
doaj   +1 more source

Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?

Frontiers in Immunology
Chronic inflammatory skin diseases are multifactorial diseases that combine genetic predisposition, environmental triggers, and metabolic disturbances associated with abnormal immune responses.
Laure Migayron, Laure Migayron, Sylvie Bordes, Brigitte Closs, Julien Seneschal, Julien Seneschal, Katia Boniface   +6 more
doaj   +1 more source

Career : a changing concept

, 1990
School of ...
Elkin, Graham
core  

Mechanical solar motor: A concept [PDF]

, 1975
Motor is proposed to convert radiation from sun directly into mechanical energy. Motor utilizes thermal expansion of liquid, heated by sun, as driving force.
Hein, L. A., Myers, W. N.
core   +1 more source

Reflection on modern methods: risk ratio regression—simple concept yet complex computation [PDF]

, 2022
Murthy Mittinty, John Lynch
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

New motor shaft angular accelerometer concept [PDF]

, 1973
Concept permits measurement of the acceleration of continuously rotating shafts without use of slip rings or telemetry and with little additional inertial load.
Smetana, F. O.
core   +1 more source