Results 111 to 120 of about 10,506,870 (352)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The 100-Days: Physical Exercise and Challenges to Assess, Maintain and Improve Physical Fitness During Lockdown

Sports
The COVID-19 pandemic reduced physical activity and increased sedentary behavior, raising health risks. To combat this, a 100-day training program was designed to maintain and improve fitness during lockdown. This program, which included a challenge with
Tommaso Di Libero, Annalisa D’Ermo, Beatrice Tosti, Stefano Corrado, Pierluigi Diotaiuti, Angelo Rodio   +5 more
doaj   +1 more source

Four-way, full-throttling valve concept [PDF]

, 1970
Valve regulates the flow of a fluid over the limits from full flow in one direction to full flow in the opposite direction. At the midpoint valve position both flow paths are closed.
Shockey, J. S.
core   +1 more source

Concept and proof for an all-silicon MEMS micro speaker utilizing air chambers [PDF]

, 2019
Bert Kaiser, S. Langa, Lutz Ehrig, Michael Stolz, Hermann A. G. Schenk, Holger Conrad, Harald Schenk, Klaus Schimmanz, David Schuffenhauer   +8 more
openalex   +1 more source

Current Advances in the Concept of Quorum Sensing-Based Prevention of Spoilage of Fish Products by Pseudomonads [PDF]

, 2022
Natalia Tomaś, Kamila Myszka
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Single-component-based multicolor emissions enabled by symmetry breaking

Nature Communications
Excitation-dependent multicolor emission from a single-component system, independent of aggregation, remains a fundamental challenge due to inherent difficulties in innovative principles.
Simin Lin, Xubin Wang, Huisi Li, Jiancheng Zhou, Ruijuan Wen, Jianfei Ma, Shiwei Yin, Ling-Ya Peng, Haonan Peng, Yu Fang   +9 more
doaj   +1 more source

Mediating the Sublime: Immersive Encounters with Goya and Munch

Museum & Society
Contributing to ongoing debates surrounding immersive experiences in museums, this essay proposes the aesthetic category of the sublime as a productive framework for immersive mediation and exhibition-making.
Nikita Mathias
doaj   +1 more source

Deep space FM system, a concept [PDF]

, 1968
Deep space frequency modulation system permits transmission of data where the signal deviation is greater than 1/2 the predetection bandwidth.
Doland, G. D.
core   +1 more source

A Proof‐of‐Concept Study of Using a Less Permeable Slice Along the Shoreline to Increase Fresh Groundwater Storage of Oceanic Islands: Analytical and Experimental Validation [PDF]

, 2019
Chunhui Lu, Hongfan Cao, Jing Ma, Wenlong Shi, Saubhagya Singh Rathore, Jichun Wu, Jian Luo   +6 more
openalex   +1 more source