Results 111 to 120 of about 14,451,026 (391)

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Wide alar base: Minimally invasive intraoral interalar suture for enhancing facial aesthetics

open access: yesAdvances in Oral and Maxillofacial Surgery, 2023
Stella Aparecida de Andrade Pinto   +4 more
doaj   +1 more source

Gas-operated actuator: A concept [PDF]

open access: yes, 1973
Recyclable actuator does depend on valves for its operation. Palladium cathode tube in electrochemical cell is used to generate hydrogen by electrolysis. Hydrogen pressure generated inside tube causes expansion of bellows, which raises load.
Simmonds, P. G.
core   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Mechanical solar motor: A concept [PDF]

open access: yes, 1975
Motor is proposed to convert radiation from sun directly into mechanical energy. Motor utilizes thermal expansion of liquid, heated by sun, as driving force.
Hein, L. A., Myers, W. N.
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Mediating the Sublime: Immersive Encounters with Goya and Munch

open access: yesMuseum & Society
Contributing to ongoing debates surrounding immersive experiences in museums, this essay proposes the aesthetic category of the sublime as a productive framework for immersive mediation and exhibition-making.
Nikita Mathias
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

251 The use of small molecule inhibitors to target novel pathways in exhausted T cells for immuno-oncology therapeutic intervention

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Preeti Singh   +8 more
doaj   +1 more source

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