Results 61 to 70 of about 2,509,605 (319)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The prevalence and burden of heavy menstrual bleeding, and market access barriers of medical interventions with a focus on low- and middle-income countries: a scoping review

BMC Women's Health
Background Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss that negatively affects physical, emotional, social, and quality of life (QoL) of women at reproductive age.
Anne Ammerdorffer, Odyssée Ferrillo, Kate Mills, Tahlia Guneratne, Maureen Makama, Lorena Romero, Annie R.A. McDougall, Jen Sothornwit, Pisake Lumbiganon, M. Valeria Bahamondes, Jennifer Scott, Lester Chinery, Luis Bahamondes, Joshua P. Vogel, A. Metin Gülmezoglu   +14 more
doaj   +1 more source

Cardiovascular Risk Factors in Socioeconomically Disadvantaged Populations in a Suburb of the Largest City in Western Romania

Biomedicines
Background and Objectives: Cardiovascular disease (CVD) remains a major public health issue worldwide, disproportionately affecting socioeconomically disadvantaged populations due to the social determinants of health (SDOHs).
Andreea Dumitrescu, Gabriela Mut Vitcu, Svetlana Stoica, Septimiu Radu Susa, Emil Robert Stoicescu   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Conservation implications of the refugee species concept and the European bison: king of the forest or refugee in a marginal habitat? [PDF]

, 2011
Graham I. H. Kerley, Rafał Kowalczyk, Joris P. G. M. Cromsigt   +2 more
openalex   +1 more source

Expert model of risk assessment for the selected components of smart city concept: From safe time to pandemics as COVID-19

, 2022
Beáta Gavurová, Мирослав Келемен, Volodymyr Polishchuk   +2 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

An Application of Crystal Plasticity to predict Forming Limit Curve of Dual-Phase Steels with Validation [PDF]

MATEC Web of Conferences
In this paper an alternative approach for generating Forming Limit Curve (FLC) of a Dual-Phase (DP800) steel is presented and validated. Investigation was performed using a rate-dependent crystal plasticity (CP) framework solved through a spectral solver
Venkata Kiranmayi Abburi, Uppaluri Rohith, Pilthammar Johan, Gutkin Renaud   +3 more
doaj   +1 more source