Results 71 to 80 of about 2,509,605 (319)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Modelling the economic impact of substandard uterotonics on postpartum haemorrhage in Nigeria: safeguarding medicine quality can reduce costs and contribute towards universal health coverage

open access: yesBMJ Public Health
Introduction Little evidence exists on the economic threat that substandard uterotonics pose to postpartum haemorrhage (PPH), maternal mortality, and national health systems.
Ahmet Metin Gülmezoglu   +7 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Expansion of Tubular with Elastomers in Multilateral Wells

open access: yesThe Journal of Engineering Research, 2013
The use of solid expandable tubular technology during the last decade has focused on solving many challenges in well drilling and delivery including zonal isolation, deep drilling, conservation of hole sizes, etc.
Md Velden, FKS Al-Jahwari
doaj   +1 more source

State Sovereignty: Concept and Conceptions

open access: yesInternational Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique
AbstractThe terms “sovereignty” and “state” are used very loosely in scholarly literature. “State sovereignty” is central to many scholarly disciplines and controversial real case scenarios, including territorial disputes; pandemics; arms, drug and human trafficking; terrorism; and the flow of refugees.
openaire   +2 more sources

On Concept of Concept

open access: yesWorld Journal of Education and Humanities, 2019
It gives Prof. Zhiyong Dong’s own definition of the concept of concept.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Wide alar base: Minimally invasive intraoral interalar suture for enhancing facial aesthetics

open access: yesAdvances in Oral and Maxillofacial Surgery, 2023
Stella Aparecida de Andrade Pinto   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

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