Results 71 to 80 of about 1,900,668 (269)

On Concept of Concept

World Journal of Education and Humanities, 2019
It gives Prof. Zhiyong Dong’s own definition of the concept of concept.
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Wide alar base: Minimally invasive intraoral interalar suture for enhancing facial aesthetics

Advances in Oral and Maxillofacial Surgery, 2023
Stella Aparecida de Andrade Pinto, José Hyczy Fonseca Junior, Renata Sari Precetti, Danilo Siqueira Pino, Francisco José de Nadai Dias   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

251 The use of small molecule inhibitors to target novel pathways in exhausted T cells for immuno-oncology therapeutic intervention

Journal for ImmunoTherapy of Cancer, 2021
Preeti Singh, Francis Acklam, Joanne Hay, Darryl Turner, Mark Barbour, Courtney Grant, Hayley Gooding, Justyna Rzepecka, Rhoanne McPherson   +8 more
doaj   +1 more source

Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?

Frontiers in Immunology
Chronic inflammatory skin diseases are multifactorial diseases that combine genetic predisposition, environmental triggers, and metabolic disturbances associated with abnormal immune responses.
Laure Migayron, Laure Migayron, Sylvie Bordes, Brigitte Closs, Julien Seneschal, Julien Seneschal, Katia Boniface   +6 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Tapping into tradition: a multi-method approach for reviving Tanka for climate-resilient water management in Ahmedabad

Built Heritage
Ahmedabad, a city that is layered with centuries of traditional knowledge systems, showcases a unique adaptation to socio-environmental and economic challenges.
Piyush Pandya, Maniti Desai, Debalina Ghosh   +2 more
doaj   +1 more source