Results 51 to 60 of about 36,563 (251)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Comparing expert and novice concept map construction through a talk-aloud protocol
, 2016 Concept maps can be used as generative assessment tools to identify changes in learner’s understanding. However, concept map analysis usually only focuses on the final product.
Schwendimann, Beat Adrian +1 more
core +1 more source
Expert Finding System in E-Learning: Using Concept Maps
International Journal of Information and Communication Technology Research, 2011 Finding subject experts for problem solving is an important issue in e-learning environment. In e-learning environment there is no direct way to find the superior individuals.
Ahmad Kardan, Fatemeh Hendijanifard
doaj
Intelligent information extraction from scholarly document databases
Journal of Intelligence Studies in Business, 2020 Extracting knowledge from big document databases has long been a challenge. Most researchers do a literature review and manage their document databases with tools that just provide a bibliography and when retrieving information (a list of concepts and ...
Fernando Vegas Fernandez
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Semi-Automatic Concept Map Generation Approach of Web-Based Kit-Build Concept Map Authoring Tool
, 2021 Apart from contributing to students’ learning outcomes, learning activities with digital concept maps were useful, fun, and engaging. Kit-Build concept map is a learning framework that incorporated concept map recomposition as its essential activity.
Pinandito, Aryo +3 more
core
Economica, 2013 Penelitian ini dilaksanakan di SMA Negeri 16 Padang pada bulan Mei-Juni 2013. Jenis penelitian ini adalah penelitian eksperimen. Populasi dalam penelitian ini adalah seluruh siswa kelas X di SMA Negeri 16 Padang sebanyak 292 orang, dengan sampel 73 orang
jolianis koto
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source