Results 51 to 60 of about 411,580 (297)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
O Papel dos Mapas Conceituais na Educação Médica
Revista Brasileira de Educação MédicaNo âmbito do ensino da medicina, diante das imperiosas mudanças necessárias para a formação de um profissional que aprenda a aprender, a aprendizagem significativa de David Ausubel - pressuposto teórico para a construção de mapas conceituais - tem ...
Andréia Patrícia Gomes +3 more
doaj +1 more source
DigiDocMap conceptual maps editor and topic maps norms [PDF]
, 2005 This article is structured in two parts, in the first part the differences and similarities between the conceptual maps of the Novak proposal (19984) and the Topic Maps standard (ISO/IEC 13250) are analysed.
Rovira, Cristòfol, Cristòfol Rovira
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effects of computer-supported collaboration script and incomplete concept maps on web design skills in an online design-based learning environment [PDF]
, 2012 Web design skills are an important component of media literacy. The aim of our study was to promote university students’ web design skills through online design-based learning (DBL).
El-Refai, Walid
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Skeleton Maps in Anatomy and Physiology: Student Perceptions
Canadian Journal for the Scholarship of Teaching and LearningHeavy content, high volume courses commonly create challenges for undergraduate students. Two such courses at our university are the introductory semesters of anatomy and physiology for first-year nursing students, taught by biology instructors. Despite
Michelle Yeo +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source