Results 111 to 120 of about 348,254 (301)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Bagaimana Penguasaan Konsep Siswa pada Materi Fluida Statis?

open access: yesJurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2019
: The purpose of this study is to determine the increase of mastery concept in static fluid in inquiry learning with theoretical empirical reviews. The research method uses descriptive analysis.
Atika Isnaining Dyah   +2 more
doaj   +1 more source

STRATEGI PEMBELAJARAN INTERTEKSTUAL DENGAN PROCESS ORIENTED GUIDED INQUIRY LEARNING (POGIL) PADA KONSEP TINGKAT KEJENUHAN LARUTAN UNTUK MENINGKATKAN PENGUASAAN KONSEP DAN KETERAMPILAN PROSES SAINS SISWA [PDF]

open access: yes, 2015
Penelitian ini bertujuan untuk mengembangkan strategi pembelajaran intertekstual dengan POGIL pada konsep tingkat kejenuhan larutan untuk meningkatkan penguasaan konsep dan keterampilan proses sains siswa dengan metode penelitian deskriptif.
Wulandari, Kiki Maya
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Penguasaan Konsep Siswa pada Model Pembelajaran Interactive Demonstration disertai Formative Feedback

open access: yesJurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2018
: This research was aimed to analyze the mastery of the concept of pressure on interactive demonstration learning model with formative feedback. The study involved 45 students of class VIII SMP Negeri 2 Rembang. The learning process is designed using the
Suryaningsasi Suryaningsasi   +2 more
doaj   +1 more source

Penerapan Media Simulasi Virtual untuk Meningkatkan Penguasaan Konsep Listrik Dinamis melalui Pembelajaran Kontekstual di Sman 4 Pekanbaru [PDF]

open access: yes, 2017
The aims this study to determine the incresing dynamic electric concepts with the application of virtual simulation media through contextual learning in class X SMAN 4 Pekanbaru. The subjects were students of class X1 and X2 class.
Ma’aruf, M. (Ma’aruf)   +2 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Penggunaan Multimedia Cai Pada Pembelajaran Mekanik Otomotif Kompetensi Pemeliharaan Rem Hidrolik Di SMK [PDF]

open access: yes, 2010
The implementation of vocational school curriculum was noticed a difference learning from complexand abstract concepts become more simple, concrete, and easy to understand. One solution to handle thatproblem is a multimedia learning with CAI.
Hendarwin, H. (Hendry)   +1 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The Effect of Guided Inquiry Learning with Multi Representation of the Science Process Skills and Concepts Mastery of Natural Science of Junior High School Students

open access: yesJurnal Pendidikan Sains, 2015
Pengaruh Pembelajaran Inkuiri Terbimbing dengan Multi Representasi terhadap Keterampilan Proses Sains dan Penguasaan Konsep IPA Siswa SMP   Abstract: The aims of this study to determine the effect of guided inquiry learning with multi representations ...
Muhammad Rizal
doaj   +1 more source

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