Results 111 to 120 of about 851,834 (314)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
We are not even allowed to call them patients anymore: Conceptions about person‐centred care
Health ExpectationsAlthough the implementation of person‐centred care (PCC) has gained momentum in healthcare systems, it is not always obvious why it is an important objective in clinical settings and educational institutions that train future healthcare professionals ...
Sylvia Määttä, Ida Björkman
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Teachers' and students' conceptions of the professional world [PDF]
, 2003 In the original 'Improving Student Learning' project led by Prof Graham Gibbs in 1991, one of the case studies focused on approaches to learning on a BA(Hons) Graphic Information Design course.
Davies, Allan, Reid, Anna
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Patient Preference and Adherence, 2017 Ingrid Larsson1,2 1School of Health and Welfare, Halmstad University, 2Spenshult Research and Development Center, Halmstad, Sweden Background: Biological therapies are common in the treatment of patients with chronic inflammatory arthritis (CIA ...
Larsson I
doaj
Conceptions of Press Freedom in a Globalising World [PDF]
, 2012 Article to accompany a talk given on 22 October 2008 at the Cambridge Festival of ...
O'Neill, Onora
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fostering relational thinking while negotiating the meaning of the equal sign [PDF]
, 2006 In this article, we relate an experience in which we have used number sentences to begin to develop algebraic thinking. Working with third-graders during six sessions, we set out to explore the following questions: How do students’ conceptions of the ...
Ambrose, Rebecca, Molina, Marta
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