Results 101 to 110 of about 270,662 (239)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

CONSIDERATIONS UPON DESIGNING MODULAR CONSTRUCTIONS FOR IMPROVING THE PRODUCTS ASSEMBLING, MAINTENANCE AND RECYCLING PROCESSES

Journal of Industrial Design and Engineering Graphics, 2015
Modular constructions are frequently used in industry because of their multiple advantages. Used from the antiquity as a measuring system that ensured good proportions for the objects or buildings, the module is used in present industry as a tool for ...
Lucian Barsan, Anca Barsan
doaj  

Conceptual Design of a Novel Autonomous Water Sampling Wing-in-Ground-Effect (WIGE) UAV and Trajectory Tracking Performance Optimization for Obstacle Avoidance

Drones
As a fundamental part of water management, water sampling treatments have recently been integrated into unmanned aerial vehicle (UAV) technologies and offer eco-friendly, cost-effective, and time-saving solutions while reducing the necessity for ...
Yüksel Eraslan
doaj   +1 more source

Dynamic capabilities of maritime infrastructure: conceptual design of merchant vessels with usability in crisis. [PDF]

J Mar Sci Technol, 2023
Hirayama S, Ichinose Y, Wanaka S, Moser B, Hiekata K.   +4 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Multiscale Conceptual Design of a Scalable and Sustainable Process to Dissolve and Regenerate Keratin from Chicken Feathers. [PDF]

Ind Eng Chem Res, 2023
Ferro VR, Leiva H, Cadena E, Valverde JL.   +3 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Conceptual design and optimization of a sustainable and environmentally friendly archetypal helicopter within the selection criteria and limitations. [PDF]

Heliyon, 2023
Gunaltili E, Ekici S, Kalkan A, Gocmen FE, Kale U, Yilmazoglu Z, Karakoc TH.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Conceptual Design of the "Private Car" Self-Isolation Ecosystem for the 2019-nCoV Infection. [PDF]

Int J Environ Res Public Health, 2022
Wang Y, Wang L, Wu X, Ding Z, Zheng W, Liang X, An H.   +6 more
europepmc   +1 more source