Results 71 to 80 of about 270,662 (239)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Editorial: Transformable structures and envelopes in architecture and civil engineering

Frontiers in Built Environment, 2023
Marios C. Phocas, Maria Matheou
doaj   +1 more source

Enhancing the Perceived Quality of a Vehicle Sliding Door Inner Handle Concept Design

Applied Sciences
Customers can always verbalize their feelings about a product, but engineers can only methodically improve what they measure in a robust and reliable manner. There is a need to convert customer needs into technical parameters. The aim of this study is to
Emel Unlukal Ilhan, Rukiye Ertan, Kenan Sert   +2 more
doaj   +1 more source

Conceptual design summary [PDF]

, 1992
The Advanced Neutron Source (ANS) is a new basic and applied research facility based on a powerful steady-state research reactor that provides beams of neutrons for measurements and experiments in the fields of materials science and engineering, biology, chemistry, materials analysis, and nuclear science.
openaire   +4 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An approach to machine tools structure selection for wooden product machining based on evidence networks [PDF]

FME Transactions, 2016
During the product development phase, especially in the case of innovative products, designers used to face the unpleasant situation to be obliged to take decisions under conditions which are characterized by a relevant degree of uncertainty and even ...
Đapić Mirko, Lukić Lj., Pavlović A.
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HighNESS conceptual design report: Volume I

Journal of Neutron Research
The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS)
Santoro V., Abou El Kheir O., Acharya D., Akhyani M., Andersen K. H., Barrow J., Bentley P., Bernasconi M., Bertelsen M., Beßler Y., Bianchi A., Brooijmans G., Broussard L., Brys T., Busi M., Campi D., Chambon A., Chen J., Czamler V., Deen P., DiJulio D. D., Dian E., Draskovits L., Dunne K., El Barbari M., Ferreira M. J., Fierlinger P., Fröst V. T., Folsom B. T., Friman-Gayer U., Gaye A., Gorini G., Gustafsson A., Gutberlet T., Happe C., Han X., Hartl M., Holl M., Jackson A., Kemp E., Kamyshkov Y., Kittelmann T., Klinkby E. B., Kolevatov R., Laporte S. I., Lauritzen B., Lejon W., Linander R., Lindroos M., Marko M., Damián J. I. M., McClanahan T. C., Meirose B., Mezei F., Michel K., Milstead D., Muhrer G., Nepomuceno A., Neshvizhevsky V., Nilsson T., Odén U., Plivelic T., Ramic K., Rataj B., Remec I., Rizzi N., Rogers J., Rosenthal E., Rosta L., Rücker U., Samothrakitis S., Schreyer A., Selknaes J. R., Shuai H., Silverstein S., Snow W. M., Strobl M., Strothmann M., Takibayev A., Wagner R., Willendrup P., Xu S., Yiu S. C., Yngwe L., Young A. R., Wolke M., Zakalek P., Zavorka L., Zanini L., Zimmer O.   +89 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

DESIGN, MODELLING AND SIMULATION OF A GRILL-ROTISSERIE ASSEMBLY

Journal of Industrial Design and Engineering Graphics, 2021
This paper proposes the conceptual design and modelling by iterative improvements of two concepts of grill-rotisserie assembly, based on the idea of multifunctionality.
Cosmin-Gabriel BIRZU, Daniel DOBRE
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