Results 61 to 70 of about 4,340,597 (294)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Semantic Integration of Conceptual Models
, 2017 In a collaborative conceptualisation process, the existence of several solutions for a given domain is a very common problem. Given this, specialists must reach a consensus on the concepts that will encompass the final solution. Therefore, this work aims to provide a tool for the integration of conceptual models in order to help specialists during the ...
Luís Costa +2 more
openaire +3 more sources
Augmented hyperbooks through conceptual integration
Proceedings of the sixteenth ACM conference on Hypertext and hypermedia, 2005 We describe the automatic transformation of a traditional electronic document into a augmented, virtual document. After converting the content into a "small-scale" hyperbook structure with an ontology and textual fragments, we calculate semantic similarity relations between the concepts of this hyperbook and a reference hyperbook.
Falquet, Gilles +2 more
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Organisational knowledge integration: towards a conceptual framework [PDF]
, 2012 This study analyses organisational knowledge integration processes from a multi-level and systemic perspective, with particular reference to the case of Fujitsu.
Kavoos Mohannak, Mohannak, Kavoos
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Destinationscape: An Integrated and Holistic Conceptualization
European Journal of Tourism ResearchDestinations are growingly acknowledged as dynamic entities requiring strategic resource management to provide value for stakeholders. In this sense, to be recognized as desirable places to visit, to live or to invest in, with a harmonious integration among the stakeholders, it is imperative to frame destinations’ distinctiveness using the experience ...
Bender, Ana Carolina +2 more
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Integrative Bioethics: A Conceptually Inconsistent Project [PDF]
Bioethics, 2015 ABSTRACTThis article provides a critical evaluation of the central components of Integrative Bioethics, a project aiming at a bioethical framework reconceptualization. Its proponents claim that this new system of thought has developed a better bioethical methodology than mainstream Western bioethics, a claim that we criticize here.
Ivanković, Viktor, Savić, Lovro
openaire +4 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source