Results 101 to 110 of about 11,269 (252)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2018 This chapter provides a conceptual map of scientism: an overview of the varieties of scientism and their relations. It argues that a plausible understanding of scientism is the thesis that the boundaries of natural science should be expanded in order to include academic disciplines or realms of life that are widely considered not to belong to the realm
openaire +3 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Building Conceptual Maps: An Integrated Teaching Approach
, 2006 The idea of 'conceptual map' was introduced by Novak and Gowin in 1989, and its role as one of the strategies that allow the organization of knowledge has been widely accepted, in particular, in the field of teaching (Buzan, 2000). The core idea was that
BIANCHI, FRANCESCA +2 more
core
Conceptual model to prepare the maps of land suitability for walnut cultivation in Iran using GIS.
, 2019 Conceptual model to prepare the maps of land suitability for walnut cultivation in Iran using GIS.
Saadat Sarikhani (6889802) +4 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Heuristic Transformation of Well-Constructed Conceptual Maps into OWL Preliminary Domain Ontologies
, 2008 . Ontologies are a form of knowledge representation that is meant for software systems, or agents, as well as for human users. Building an ontology consists of, in short, formally specifying concepts and their relations concerning a certain knowledge ...
Gretchen T. Macedo +2 more
core
Examining mathematics teachers’ perceptions of concept mapping to facilitate meaningful learning
InfinityConcept maps enhance the quality of learning, as they can promote meaningful learning. However, teachers rarely integrate concept maps into their instructional practices.
Rahmah Johar +4 more
doaj +1 more source