Results 61 to 70 of about 113,206 (264)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Conceptual metaphor as the meaning embodiment of the modern folklore text [PDF]

Актуальные проблемы филологии и педагогической лингвистики
The article analyzes the metaphorical nature of language within the framework of cognitive linguistics and its manifestations in modern folklore texts. The study examines conceptual metaphors as universal cognitive structures.
Larisa E. Ilyina
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Conceptualizing transdisciplinarity: How do visuals mean?

Environmental Science & Policy
Transdisciplinary research is commonly understood as a research collaboration between different academic disciplines and actors from different sectors of society to co-produce knowledge needed in addressing real-world problems. In this paper, we understand transdisciplinary research as an epistemological object and study how researchers conceptualize ...
van Hulst, Merlijn, Holstead, Kirsty, Metze, Tamara   +2 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Embodied Design Thinking

She Ji: The Journal of Design, Economics and Innovation, 2019
This article explores the thought processes of design thinking as an embodied process of experience. This conceptualization frames design thinking as an outcome of mind that functions as brain-body-in-the-world.
Jerry Diethelm
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Classification of Conceptual Variation of Terms Based on the Semantic Discursive Modulation

Ikala: Revista de Lenguaje y Cultura, 2011
This paper describes a proposal to classify the conceptual variation of terms represented by regular and irregular polysemic processes to which terms as lexical units are subjected in discourse.
Irina Kostina
doaj  

The The potential of words to become swearing: an ethno semantic study

Bahastra
This research aims to describe the potential of words as swear words through an ethno semantic study. This research differs from other swearing studies examining the form and meaning of swear words.
Fitri Amilia, Astri Widyaruli Anggraeni, Anita Fatimatul Laeli, Edwar Kemal   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source