Results 121 to 130 of about 552,487 (315)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
AI Communications 16 (2003) 279--289 279 IOS Press
, 2004 This paper presents and motivates the use of a given knowledge representation designed to facilitate the knowledge sharing from heterogeneous sources for problem solving in environmental processes using an Agent based technology.
Conceptual Model To
core
Application of context knowledge in supporting conceptual design decision making
, 2010 Conceptual design is the most important phase of the product life cycle as the decisions taken at conceptual design stage affect the downstream phases (manufacture, assembly, use, maintenance, and disposal) in terms of cost, quality and function ...
Xiu Tian Yan +4 more
core +1 more source
ITI 2002. Proceedings of the 24th International Conference on Information Technology Interfaces (IEEE Cat. No.02EX534), 2003 Three steps in data modelling include conceptual, logical and physical modelling. The conceptual modelling models data from the users’ ; ; perspective independently from any logical and physical implementation. The paper discusses different conceptual modelling styles that may apply in modelling transactional and analytical information system.
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Frontiers in Environmental EconomicsThis paper aims to contribute to the ongoing discourse regarding the distinctions and application of scoring and rating systems by presenting a conceptual model designed to assess and self-assess small and medium-sized enterprises (hereinafter also “SMEs”
Pina Murè +4 more
doaj +1 more source
A Conceptual Teacher-Learner Model for a Collaborative Learning with Serious Games
, 2012 This paper introduces a conceptual Teacher-Learner framework for a collaborative learning with serious games. An initial study identified twelve attributes of educational serious games that can be used to support effective learning.
Yusoff, Amri +3 more
core
The notion of role in conceptual modeling
, 1997 Dates de conf{\'e}rence : octobre 1997 ...
Chantal Reynaud +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source