Results 111 to 120 of about 557,360 (315)

A Conceptual Teacher-Learner Model for a Collaborative Learning with Serious Games [PDF]

, 2012
This paper introduces a conceptual Teacher-Learner framework for a collaborative learning with serious games. An initial study identified twelve attributes of educational serious games that can be used to support effective learning.
Yusoff, Amri, Gilbert, Lester, Crowder, Richard M., Wills, Gary   +3 more
core  

Effects of the vadose zone on groundwater flow and solute transport characteristics in mountainous karst aquifers – the case of the Javorniki–Snežnik massif (SW Slovenia)

Acta Carsologica, 2018
Tracer tests are rarely applied in mountainous karst aquifers due to difficult or limited basic data acquisition, problems of access and expected strong tailing effects in tracer breakthrough.
Metka Petrič, Janja Kogovšek, Nataša Ravbar   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Adherence to anti-hypertensive medication: Proposing and testing a conceptual model [PDF]

, 2011
Objectives. A conceptual model of the psychological factors underpinning adherence to anti-hypertensive medication is proposed and tested. The model suggests that adherence is influenced by three sets of variables: demography, health status, and ...
Derek R. Rutter, Rutter, D., Susan Thompson, Quine, L., Thompson, S., Rutter, D. R., Liz Steadman, Lyn Quine, Steadman, L.   +8 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Conceptual Design of High-rises with Parametric Methods [PDF]

, 2007
This paper describes the use of parametric methods in generating conceptual designs of high-rise buildings. We first assess current conceptual design practice at a leading AE firm and illustrate the challenge of satisfying a complex set of requirements ...
V. Gane, J. Haymaker
core  

Conceptual Model Of Resolution

, 2017
In this document, we look at three aspects of the resolution of identifiers to a URI representing the resource: dynamic data citation, content negotiation, and machine-enabled licence information.
Fenner, Martin, Petryszak, Robert, Kotarski, Rachael   +2 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source