Results 91 to 100 of about 16,017,577 (292)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Conceptual Model Of Resolution
, 2017 In this document, we look at three aspects of the resolution of identifiers to a URI representing the resource: dynamic data citation, content negotiation, and machine-enabled licence information.
Fenner, Martin +2 more
openaire +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A conceptual model of customer relationship management alignment [PDF]
, 2012 The paper proposes a conceptual model of customer relationship management (CRM) alignment. The research adopts the business-information systems (IS) strategic alignment model, CRM process and technology perspectives and effectiveness of CRM as a basis ...
Kaur, Jasber +5 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The conceptual model and key technologies of PLM
, 2004 PLM - a completely new business approach -has been evolved from the early PDM in recent years, and the PLM solutions can offer a concrete integration environment to effectively develop and manage the data of products and processes; also can be the utmost
Li HY(李海越) +3 more
core
Digital Transformation in Hospitality Services: Conceptual Framework and Managerial Implications [PDF]
Ovidius University Annals: Economic Sciences SeriesDigital transformation has become a defining factor in the evolution of hospitality services, reshaping operational models, customer interaction and value creation processes. This paper presents a conceptual framework that synthesizes the main theories
Roxana-Marcela Zaharia +2 more
doaj
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
PENGGUNAAN FISIKAL MODEL DALAM PERANCANGAN ARSITEKTUR
, 2013 One important factor in architectural design process that are used is physical model. Information and design solutions for the architectural design process can be obtained using physical model.
model, architecture design, physical +1 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source