Results 81 to 90 of about 16,017,577 (292)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modelling of Regional Economy Growth Strategy
Управленческие науки, 2017 Introduction, Purpose. Management of the regional economy development is experiencing rather serious methodological and instrumental difficulties. The diversified institutional constraints, private ownership of the companies do not allow constructively ...
I. S. Mezhov, E. V. Kletskova
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Introducing the StEWARD framework: a perspective on the Coach Supervisor Mindset
International Journal of Evidence Based Coaching and MentoringBuilding on previous research, this article identifies an acronym “StEWARD” as a framework for articulating and exploring a coach supervision mindset. The acronym stands for Stewardship, Exploring, Wisdom, Agility, Relationship and Doubt, the letter “t ...
Michelle Lucas
doaj +1 more source
Perspectives Interdisciplinaires sur le Travail et la Santé, 2013 The scientific literature increasingly recognizes the multifactorial origin of non-traumatic, work-related musculoskeletal disorders (WMSD). Beyond the contribution of biomechanical and personal factors, many organizational and psychosocial factors have ...
Susan Stock +4 more
doaj +1 more source
Russian Journal of Agricultural and Socio-Economic Sciences, 2021 In the context of regional development, coastal reclamation is expected to increase the overall carrying capacity and environmental carrying capacity of the area. However, along the way, the reclamation project did not always succeed as expected. Several
Yustiana D. +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2002 Management consulting firms are considered typical examples of highly knowledge-intensive companies since they depend heavily on the expertise of their people and the nature of their assignments is knowledge-based.
Reena J. Sarkar +3 more
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Topografski informacijski sistem Bosne in Hercegovine – konceptualni in logični model : Topographic information system of Bosnia and Herzegovina – conceptual and logical model [PDF]
Geodetski Vestnik, 2007 The conceptual and logical data models of the topographic information system, which is equal to the content of the topographic map in scale 1:25,000 for Bosnia and Herzegovina (BiH), has been defined.
Admir Mulahusić +2 more
doaj