Results 71 to 80 of about 557,360 (315)
A Conceptual Model for Engineering Educators in Rural Places: Critical Reflection and Engagement
Studies in Engineering EducationRural educational contexts often go under addressed in engineering education research and practice. Given the specific nuances associated with rural places and contexts, engineering education outreach should be better aligned with ongoing efforts to ...
Malle R. Schilling, Jacob R. Grohs
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The conceptual model and key technologies of PLM [PDF]
, 2004 PLM - a completely new business approach -has been evolved from the early PDM in recent years, and the PLM solutions can offer a concrete integration environment to effectively develop and manage the data of products and processes; also can be the utmost
Li HY(李海越) +3 more
core
Lingvokognitivnyj analiz diskursa: ponâtijno-terminologičeskij apparat issledovaniâ
Stylistyka, 2019 This article is devoted to the linguistic and cognitive analysis of discourse. The article defines the basie terms and concepts, which are concepts and terminology by linguistic and cognitive analysis oť discourse, explores techniques for conceptual ...
Elena G. Malyševa
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Incorporating business requirements and constraints in database conceptual models [PDF]
, 2004 Entity relationship (ER) approach is predominantly used for conceptual modelling of database systems in terms of entities and their relationships. The approach does not provide sufficient support for incorporating business constraints and their impact on
Khan, Khaled M. +2 more
core
Tailoring temporal description logics for reasoning over temporal conceptual models [PDF]
, 2011 Temporal data models have been used to describe how data can evolve in the context of temporal databases. Both the Extended Entity-Relationship (EER) model and the Unified Modelling Language (UML) have been temporally extended to design temporal ...
Ryzhikov, Vladislav +8 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On the evolution of conceptual modeling
, 2008 Since the 1980s the need increased for overcoming idiosyncrasies of approaches to modeling in the various sub-disciplines of computing. The theoretical model of evolution is used in this paper for analyzing how computing and conceptual modeling have changed.
openaire +4 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source