Results 61 to 70 of about 552,487 (315)
LUMAT, 2016 Games have been used for a long time in teaching and learning. The increasing use of mobile phones makes it possible to link learning outside the classroom with augmented reality (AR).
Tuomas Aivelo, Anna Uitto
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Social Advocacy: A conceptual model to extend post-intervention effectiveness
, 2023 Commercial marketing literature highlights benefits from brand advocates who recruit and promote in the interest of the commercial entity. However, a similar focus is lacking on how advocacy can extend the effectiveness of social change initiatives.
Campbell, Alexander +3 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Lingvokognitivnyj analiz diskursa: ponâtijno-terminologičeskij apparat issledovaniâ
Stylistyka, 2019 This article is devoted to the linguistic and cognitive analysis of discourse. The article defines the basie terms and concepts, which are concepts and terminology by linguistic and cognitive analysis oť discourse, explores techniques for conceptual ...
Elena G. Malyševa
doaj
Medico-social rationale for the development of digital personnel potential in healthcare
Medičnì PerspektiviThe digital transformation of the healthcare system is a key factor in improving the efficiency of medical services and sector management. One of the critical aspects of this transformation is the development of digital workforce potential, which ...
L.V. Kriachkova, K.I. Simon
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
On the evolution of conceptual modeling
, 2008 Since the 1980s the need increased for overcoming idiosyncrasies of approaches to modeling in the various sub-disciplines of computing. The theoretical model of evolution is used in this paper for analyzing how computing and conceptual modeling have changed.
openaire +4 more sources
The Conceptual LeanPPD Model [PDF]
, 2010 This paper is presenting the conceptual Lean Product and Process Development (LeanPPD) model which is a project funded by the EU-PF7. The project is addressing the needs of European manufacturing companies of a new model that goes beyond lean manufacturing, to ensure the transformation of the enterprise into lean environment.
Ahmed Al-Ashaab +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source