Results 91 to 100 of about 1,908,176 (323)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Conceptual Models for Intangible Art
Mimesis Journal, 2014 Formal ontologies have been fruitfully employed to describe and document cultural heritage with the twofold goals of providing explicit and shared conceptual models of cultural heritage and of making documentation directly available to men and machines ...
Antonio Lieto +2 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Conceptual Microarchitectures for Hydrologic Simulation Models
CLEI Electronic Journal, 2018 Mathmatical Hydrologic models simulate real world environmental processes through different strategies. Each process is calculated by means of methods that utilize physical parameters for representing the real world system.
Adriana Urciuolo +2 more
doaj +1 more source
Regression Models for Count Data in R [PDF]
The classical Poisson, geometric and negative binomial regression models for count data belong to the family of generalized linear models and are available at the core of the statistics toolbox in the R system for statistical computing.
Achim Zeileis +2 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
On conceptual models for information seeking and retrieval research
Information Research: An International Electronic Journal, 2003 There are several kinds of conceptual models for information seeking and retrieval (IS&R). The paper suggests that some models are of a summary type and others more analytic. Such models serve different research purposes. The purpose of this paper is
Kalervo Jarvelin, T.D. Wilson
doaj
Frontiers in EducationIntroductionModels are a primary mode of science communication and preparing university students to evaluate models will allow students to better construct models and predict phenomena.
Joseph Dauer +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
MISCO: A Conceptual Model for MIS Implementation in SMEs
Information Research: An International Electronic Journal, 1999 Information Technology ('IT') has made a prolific impact, both in sociological and commercial terms. In the business world, the pursuit of new technology and working practices has often been at the expense of equal regard for the correct methods to ...
R.Bali, G.Cockerham, C.Bloor
doaj