Results 101 to 110 of about 23,828,011 (387)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Supply chain integration-performance nexus in emerging & developing economies: a systematic review

Cogent Business & Management
The literature on SCI-performance nexus remains inconclusive and inconsistent. This study analyses the most recent literature aiming to clarify the most important conceptualisations of SCI, identify existing performance measures, and assess the evidence ...
Goitom Abera Baisa, Dante Benjamin Matellini, Ian D. Jenkinson, Chia-Hsun Chang   +3 more
doaj   +1 more source

Software Conceptual Integrity: Deconstruction, Then Reconstruction [PDF]

arXiv, 2018
Conceptual Integrity is the most important consideration for software system design, as stated by Frederick Brooks. Brooks also suggested that Conceptual Integrity can be attained by means of design principles, such as Propriety, and Orthogonality. However, Brooks' principles have not been formalized, posing obstacles to their application in practice ...
arxiv  

Conceptual modelling: framework, principles, and future research [PDF]

, 2007
The conceptual modelling task in a simulation project is very important and yet is still generally regarded as more of an art than a science. The meaning and nature of conceptual modelling are discussed and a framework set out.
Brooks, R J
core  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Agent-Based Models and Simulations in Economics and Social Sciences: from conceptual exploration to distinct ways of experimenting [PDF]

, 2008
Now that complex Agent-Based Models and computer simulations spread over economics and social sciences - as in most sciences of complex systems -, epistemological puzzles (re)emerge. We introduce new epistemological tools so
Phan, Denis, Varenne, Franck
core   +1 more source

Health literacy and public health: A systematic review and integration of definitions and models

BMC Public Health, 2012
BackgroundHealth literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or ...
K. Sørensen, S. van den Broucke, James Fullam, G. Doyle, J. Pelikan, Z. Słońska, H. Brand   +6 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Functional requirements for bibliographic records (FRBR): an analysis of usability of control model of the bibliographic universe

Knjižnica, 2009
Two studies in connection with the Functional Requirements for Bibliographic Records (FRBR) conceptual model are presented. While the model is based on experiences of experts, it is yet to have been tested in practice.
Jan Pisanski, Maja Žumer
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source