Results 111 to 120 of about 1,908,176 (323)

Visible Light-Based Human Visual System Conceptual Model [PDF]

, 2016
Lee Prangnell
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

How do embodied experiences of asthma influence caregiver conceptual models? [PDF]

Soc Sci Med, 2022
Spray J, Hunleth J, Ruiz S, Maki J, Fedele DA, Prabhakaran S, Fechtel H, Shepperd JA, Bowen DJ, Waters EA.   +9 more
europepmc   +1 more source

The Conceptual Model of Improving The Perfomance of Madrasah Teachers [PDF]

, 2023
Liana Ariesha Khoerudin, Siti Qomariyah, Hani Sanjaya, Pepen Supendi   +3 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Climate and Human Behavior Studies for Our Warming World: An Introduction to the Models, Methods, and Data

Advances in Archaeological Practice
This article is an introduction and guide to investigating past relationships between climate and human behavior. Improving understanding of these relationships is essential as humanity confronts the challenges of our warming world.
Scott E. Ingram
doaj   +1 more source

The Structure of Bitumen: Conceptual Models and Experimental Evidences. [PDF]

Materials (Basel), 2022
Porto M, Angelico R, Caputo P, Abe AA, Teltayev B, Rossi CO.   +5 more
europepmc   +1 more source

The AtollGame Experience: from Knowledge Engineering to a Computer-Assisted Role Playing Game [PDF]

This paper presents the methodology developed to collect, understand and merge viewpoints coming from different stakeholders in order to build a shared and formal representation of the studied system dealing with groundwater management in the low-lying ...
Anne Dray, Christophe Le Page, Ian White, Natalie Jones, Pascal Perez, Patrick D'Aquino, Titeem Auatabu   +6 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Investigating the Connection Between Individual Resilience and Organisational Resilience

Systems
Resilience has become a central theme in organisational research, particularly in sectors such as construction that face frequent disruption, complexity, and uncertainty.
M. Mitansha, Regan Potangaroa
doaj   +1 more source