Results 91 to 100 of about 5,453,078 (289)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Development of Scenarios as Problem-Space Descriptions in Aerospace Conceptual Design

open access: yesAerospace
In the defense and security domain, scenarios are often descriptions of stakeholder needs, future events, and the environment. They are used for the elicitation of requirements in development of capabilities, organizations, and technical systems.
Karl Kindström Andersson   +1 more
doaj   +1 more source

El lenguaje figurado de las alianzas empresariales

open access: yesCuadernos de Investigación Filológica, 2013
La metáfora desempeña un papel fundamental en la lengua. Este artículo analiza el uso extendido de la metáfora en la prensa económica a través de las expresiones metafóricas que describen las alianzas entre empresas en Financial Times y El País.
Isabel Negro Alousque
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

METHODOLOGY FOR CREATING THE UNIFIED CONCEPTUAL SOCIO-COMMUNICATIVE SPACE

open access: yesВестник Кемеровского государственного университета, 2015
The methodological cross-disciplinary research presented here touches on linguistics, philosophy, and communicology, but its main focus lies in the sphere of sociology. The research is based on the idea of the anthropometrics of language.
L. I. Levkina
doaj  

Luray, VA: Conceptual Plan for the Page County Community Space

open access: yes, 2021
Page County has a 10-acre undeveloped parcel located in the Town of Luray limits. This gateway parcel has frontage off of HWY 211 going east toward Shenandoah National Park and Route 340 South into the Luray’s Main Street downtown district.
Gilboy, Elizabeth, Proctor, Nicholaus
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Rapid Design Space Exploration for Conceptual Design of Hypersonic Missions

open access: yes, 2011
Presented at the 2011 AIAA Atmospheric Flight Mechanics Conference in Portland, OR.During conceptual design, multidisciplinary optimization is often performed using computationally intensive direct methods.
Grant, Michael J.   +2 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

RELEVANCE, MEANING AND CONCEPTUAL REPRESENTATION IN PRINT MODERN ADVERTISING [PDF]

open access: yesStudii si Cercetari Filologice: Seria Limbi Straine Aplicate, 2011
The present study aims to underline, first of all, the interdependent relationship between meaning and relevance, following a cognitive perspective.
Ana-Maria Florescu
doaj  

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