Results 121 to 130 of about 2,902,077 (302)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Efficiently Compressible Density Operators via Entropy Maximization

Proceedings, 2019
We address the problem of efficiently and effectively compress density operators (DOs), by providing an efficient procedure for learning the most likely DO, given a chosen set of partial information.
Serena Di Giorgio, Paulo Mateus
doaj   +1 more source

Fast Nonparametric Conditional Density Estimation

CoRR, 2012
Appears in Proceedings of the Twenty-Third Conference on Uncertainty in Artificial Intelligence (UAI2007)
Michael P. Holmes, Alexander G. Gray, Charles L. Isbell Jr.   +2 more
openaire   +3 more sources

Consistent tests of conditional moment restrictions [PDF]

, 2006
We propose two classes of consistent tests in parametric econometric models defined through multiple conditional moment restrictions. The first type of tests relies on nonparametric estimation, while the second relies on a functional of a marked ...
Domínguez, Manuel A., Delgado, Miguel A., Lavergne, Pascal   +2 more
core   +2 more sources

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Modelling the Density of Inflation Using Autoregressive Conditional Heteroscedasticity, Skewness, and Kurtosis Models

Ensayos Revista de Economía, 2011
The paper aimed at modelling the density of inflation based on time-varying conditional variance, skewness and kurtosis model developed by Leon, Rubio, and Serna (2005) who model higher-order moments as GARCH-type processes by applying a Gram-Charlier ...
Doaa Akl Ahmed
doaj  

A Conditional Density Estimation Partition Model Using Logistic Gaussian Processes. [PDF]

Biometrika, 2020
Payne RD, Guha N, Ding Y, Mallick BK.
europepmc   +1 more source

A Consistent Test for Multivariate Conditional Distributions [PDF]

We propose a new test for a multivariate parametric conditional distribution of a vector of variables yt given a conditional vector xt. The proposed test is shown to have an asymptotic normal distribution under the null hypothesis, while being consistent
Greg Tkacz, Fuchun Li
core  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Expansions for the Conditional Density and Distribution of a Standard Estimate

Stats
Conditioning is a very useful way of using correlated information to reduce the variability of an estimate. Conditioning an estimate on a correlated estimate, reduces its covariance, and so provides more precise inference than using an unconditioned ...
Christopher S. Withers
doaj   +1 more source