Results 41 to 50 of about 31,428 (257)

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Wavelet Density and Regression Estimators for Continuous Time Functional Stationary and Ergodic Processes

Mathematics, 2022
In this study, we look at the wavelet basis for the nonparametric estimation of density and regression functions for continuous functional stationary processes in Hilbert space. The mean integrated squared error for a small subset is established.
Sultana Didi, Salim Bouzebda
doaj   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

CONDITIONAL DISCRIMINATION LEARNING: A CRITIQUE AND AMPLIFICATION [PDF]

Journal of the Experimental Analysis of Behavior, 1980
Carter and Werner recently reviewed the literature on conditional discrimination learning by pigeons, which consists of studies of matching‐to‐sample and oddity‐from‐sample. They also discussed three models of such learning: the “multiple‐rule” model (learning of stimulus‐specific relations), the “configuration” model, and the “single‐rule” model ...
A M, Schrier, C R, Thompson
openaire   +2 more sources

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

ANÁLISIS DEL DISCURSO DIDÁCTICO USANDO UNA TAREA DE IGUALACIÓN DE LA MUESTRA DE SEGUNDO ORDEN [PDF]

Acta Colombiana de Psicología, 2008
Learning to teach seems to be a product of direct experiential learning. Therefore, in this study, a second-order matching-to-sample task was used to evaluate the didactic discourse that a person can elaborate from his own learning.
Rodríguez Pérez, María Elena, Castellanos Meza, Félix Alejandro, Díaz Gámez, Liliana Leticia   +2 more
doaj  

Role of discrimination and resilience on birth weight: A systematic examination in a sample of Black, Latina, and White women

Women's Health, 2022
Introduction: Health inequities begin before birth with Black women being more likely to have low birth weight babies than White and Latina women. Although both Latina and Black women experience discrimination, only Black women appear to be affected ...
Kristin D Mickelson, Pooja Doehrman, Claudia Chambers, Hayley Seely, Marianna Kaneris, Rachel Stancl, Chelsea Stewart, Shea Sullivan   +7 more
doaj   +1 more source

Cue discriminability predicts instrumental conditioning

Consciousness and Cognition, 2018
Charting mental acts that succeed or fail under unconscious instances of cognition informs debates on the nature and potential functions of consciousness. A prominent method to exclude conscious contributions to cognition is to render visual stimuli unconscious by short and pattern-masked presentations.
Thomas P. Reber, Bita Samimizad, Florian Mormann   +2 more
openaire   +3 more sources

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

FORMACIÓN DE CLASES EQUIVALENTES A TRAVÉS DE REGLAS VERBALES Y FORMATO MANUAL [PDF]

Acta Colombiana de Psicología, 2008
Equivalent class formation through verbal rules was analyzed. A matching-to-sample procedure for training and probing of conditional discriminations in a “paper and pencil” format was used.
Tovar y Romo, Ángel, Torres Chávez, Álvaro   +1 more
doaj