Results 71 to 80 of about 31,428 (257)

Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators

Protein & Cell, 2020
Gene expression labeling and conditional manipulation of gene function are important for elaborate dissection of gene function. However, contemporary generation of pairwise dual-function knockin alleles to achieve both conditional and geno-tagging ...
Bingzhou Han, Yage Zhang, Xuetong Bi, Yang Zhou, Christopher J. Krueger, Xinli Hu, Zuoyan Zhu, Xiangjun Tong, Bo Zhang   +8 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Arithmetic problem-solving: effect of equivalence relations between three different forms of presenting problems / Resolução de problemas aritméticos: efeito de relações de equivalência entre três diferentes formas de apresentação dos problemas

Psicologia: Reflexão e Crítica, 2006
The equivalence paradigm has been applied to the development of a variety of procedures applied to teach reading, writing and arithmetic. This work aimed to investigate the effect of teaching stimulus equivalence relations between three different forms ...
Verônica Bender Haydu, Lucita Portela da Costa, Elsa Maria Mendes Pessoa Pullin   +2 more
doaj  

Ensino de Leitura de Orações por meio de Discriminações Condicionais

Psicologia: Teoria e Pesquisa
RESUMO Teve-se por objetivo ensinar o repertório de leitura, por meio de discriminações condicionais. A proposta, baseada no modelo de equivalência de estímulos e aplicada com software , teve orações como unidade de ensino.
Giselda Zanco, Melania Moroz
doaj   +1 more source

Conditional right eradication of all forms of Discrimination Convention Elimination [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2005
مهمترین هدف از انعقاد معاهدات بین‌المللی حقوق بشری، از جمله کنوانسیون امحای کلیه اشکال تبعیض علیه زنان، برقراری نظام هماهنگی جهت اجرای مفاد این معاهدات در سطح جهانی است.بسیاری از نویسندگان حقوقی بر این باورند که مهمترین مانع در جهت عدم تحقق این هدف ...
AZAD SEYEDI
doaj  

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Maintenance of Stimuli Equivalence Classes: A Study with Students of Fundamental School

Psicologia, 2009
The maintenance of equivalence classes is affected by many experimental variables. The present study aimed to investigate the effect of classes size on the formation and maintenance of the equivalence relations with students of the fundamental school (9 ...
Leila Cristina Ferreira Omote, Priscila Vicente, Natalia Maria Aggio, Verônica Bender Haydu   +3 more
doaj  

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model

Advanced Science, EarlyView.
In this work, CoSP (contrastive multi‐state pretrain), an intelligent inverse design method for reconfigurable metamaterials based on a contrastive pretrained large language model, is proposed. Numerical experiments demonstrate that CoSP can design reconfigurable metamaterial structures for multi‐state, multi‐band optical responses, showing great ...
Shujie Yang, Yuqi Zhang, Xuzhe Zhao, Yansong Tang, Kaichen Dong   +4 more
wiley   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Machine Psychology: integrating operant conditioning with the non-axiomatic reasoning system for advancing artificial general intelligence research

Frontiers in Robotics and AI
This paper presents an interdisciplinary framework, Machine Psychology, which integrates principles from operant learning psychology with a particular Artificial Intelligence model, the Non-Axiomatic Reasoning System (NARS), to advance Artificial General
Robert Johansson, Robert Johansson
doaj   +1 more source