Results 101 to 110 of about 44,587 (300)

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Genetic code expansion for chemosensing and chemical actuation of biological functions

Bulletin of the Korean Chemical Society, EarlyView.
Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Return condition for oscillating systems

V. N. Karazin Kharkiv National University. Ser. Mathematics, Applied Mathematics and Mechanics
This paper is devoted to the problem of null-controllability for the oscillating linear system $\dot{x}_{2i-1} = x_{2i}, \dot{x}_{2i} = - x_{2i-1} + u$, $i = \overline{1,n}$ with constraints on the control $u \in [c, 1]$ and $u \in \{c, 1\}$ in the case when the origin is not an equilibrium point.
Oleh Vozniak, Valery Korobov
openaire   +1 more source

Boundary oscillations and nonlinear boundary conditions

Comptes Rendus. Mathématique, 2006
We study how oscillations in the boundary of a domain affect the behavior of solutions of elliptic equations with nonlinear boundary conditions of the type ∂u∂n+g(x,u)=0. We show that there exists a function γ defined on the boundary, that depends on the oscillations at the boundary, such that, if γ is a bounded function, then, for all nonlinearities g,
Arrieta, Jose M., Bruschi, Simone M.
openaire   +3 more sources

Decoding Emotional Signatures of Ethical Ads: An Analysis of Actor‐Viewer Synchrony

Journal of Consumer Behaviour, EarlyView.
ABSTRACT We examine whether ethical advertisements differ from conventional ads in their on‐screen emotional signatures and whether those signatures transfer to actor‐viewer synchrony. Study 1 analyses 138 professionally produced YouTube ads using Automated Facial Expression Recognition (AFER) and Convolutional Neural Networks (CNN) to quantify actor ...
Vik Naidoo, Nicolas Hamelin
wiley   +1 more source

Asymptotic properties of cross‐classified sampling designs

Canadian Journal of Statistics, EarlyView.
Abstract We investigate the family of cross‐classified sampling designs across an arbitrary number of dimensions. We introduce a variance decomposition that enables the derivation of general asymptotic properties for these designs and the development of straightforward and asymptotically unbiased variance estimators.
Jean Rubin, Guillaume Chauvet
wiley   +1 more source

Satellite hindcasts of foliar traits reveal a subtle but consistent relaxation of conservativeness in a biodiverse mountain grassland over the last four decades

Ecography, EarlyView.
Projected warming and drying raise concerns about the resilience of stress‐adapted ecosystems, including the Brazilian Campo Rupestre, an exceptionally biodiverse mountaintop grassland mosaic on ancient, nutrient‐poor substrates. Here, we combine field‐based trait data and long‐term remote sensing to assess the functional structure and temporal ...
Renata Maia, Milton Barbosa, Daniel Negreiros, Geraldo Wilson Fernandes, Yadvinder Malhi, Jesus Aguirre‐Gutiérrez   +5 more
wiley   +1 more source

Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations

Nature Communications
The precise temporal coordination of neural activity is crucial for brain function. In the hippocampus, this precision is reflected in the oscillatory rhythms observed in CA1. While it is known that a balance between excitatory and inhibitory activity is
Chinnakkaruppan Adaikkan, Justin Joseph, Georgios Foustoukos, Jun Wang, Denis Polygalov, Roman Boehringer, Steven J. Middleton, Arthur J. Y. Huang, Li-Huei Tsai, Thomas J. McHugh   +9 more
doaj   +1 more source