Results 241 to 250 of about 2,348,563 (303)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction. [PDF]

Regen Ther
Kobuchi S, Hsu WT, Matsuzawa M, Kagawa R, Watanabe J, Harada K, Toda Y, Hamada S, Tsujimoto M, Kawashima H, Nishimura K, Matsumoto K, Takata K.   +12 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Protocol to generate species-specific astrocyte-conditioned medium for human organoid neuron maturation. [PDF]

STAR Protoc
Zheng H, Xu W, Yu F, Xu J, Jiang M, Ma N, Shao Z, Ma S.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Alpha-Lipoic Acid Reduces NLRP3/ASC Expression and IL-1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium. [PDF]

Food Sci Nutr
Ko CY, Lo YM, Nguyen TKN, Kao ST, Wu CH, Huang WC, Shen SC.   +6 more
europepmc   +1 more source

Intravenous Administration of Human-Derived Mesenchymal Stem Cell-Conditioned Medium for Patients with General Malaise. [PDF]

J Clin Med
Inami N.
europepmc   +1 more source

Therapeutic effectiveness of conditioned medium derived from adipose tissue mesenchymal stem cells and dehydroepiandrosterone in a rat model of spinal cord injury. [PDF]

IBRO Neurosci Rep
Modarresi F, Kaka GR, Raei M, Rezaei-Tazangi F.   +3 more
europepmc   +1 more source

Tissue regenerative potential of human dental pulp mesenchymal stem cell conditioned medium in wound healing of the medicinal leech. [PDF]

Stem Cell Res Ther
Marcolli G, Barone L, Baranzini N, Rossi F, Nebuloni AM, Pulze L, Sadia S, Zecca PA, Pagiatakis C, Papait R, Grimaldi A, Gornati R.   +11 more
europepmc   +1 more source

Retraction: Tumor Targeting by Conditioned Medium Derived from Human Amniotic Membrane: New Insight in Breast Cancer Therapy. [PDF]

Technol Cancer Res Treat
europepmc   +1 more source