Results 101 to 110 of about 1,540,087 (356)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Conditional Punishment [PDF]

open access: yesSSRN Electronic Journal, 2014
We elicit human conditional punishment types by conducting experiments. We find that their punishment decisions to an individual are on average significantly positively proportional to other members’ punishment decisions to that individual.
openaire   +4 more sources

Female coaches in strength and conditioning: Why so Few? [PDF]

open access: yes, 2019
A substantial issue in sporting professions today, including elite strength and conditioning is gender imbalance. Attitudes towards women’s roles are complex and institutionally entrenched, contributing to barriers to women’s success. While real issues
O'Malley, Lynne Marie
core  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Comparison of Heart Rate Intensity in Practice, Conditioning, and Games in NCAA Division I Women Basketball Players [PDF]

open access: yes, 2019
Background: An athlete’s heart rate (HR) is an important variable in quantifying the intensity of exercise. Workouts that increase HR are an important stimulus for training adaptations and conditioning.
Elliott, Courtney   +2 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Conditioned Exchange

open access: yesFOOTPRINT, 2019
The emergence of financial institutions such as the exchanges or bourses of northern Europe in the sixteenth and the seventeenth centuries made possible the emergence of speculation in financial instruments. Speculation evolved into a game with its own logic, and the implied ethos of the speculator prioritised abstract notions and self-interest. This
openaire   +4 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

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