Results 101 to 110 of about 434,913 (295)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Alemtuzumab, Fludarabine, Melphalan, and Thiotepa as a Reduced-Intensity Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation in Inborn Errors of Immunity.

Background: Allo-HCT is the only curative treatment for many inborn errors of immunity (IEI). The ideal conditioning regimen offers rapid engraftment, reduced organ toxicity, and low rates of GvHD.
Hyde, Stephanie, Quigg, Troy C, Bhatt, Sima T, Pfeiffer, Thomas, Eckrich, Michael J, Mavers, Melissa, Gao, Feng, Shenoy, Shalini, Hayashi, Robert J, Madden, Lisa   +9 more
core   +1 more source

Thiotepa-based conditioning versus total body irradiation as myeloablative conditioning prior to allogeneic stem cell transplantation for acute lymphoblastic leukemia: A matched-pair analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

, 2017
The optimal conditioning regimen to employ before hematopoietic stem cell transplantation in acute lymphoblastic leukemia (ALL) is still undecided, and while cyclophosphamide/total body irradiation (Cy/TBI) is the most commonly used myeloablative regimen,
Sanz, Jaime, Canaani, J, Gurman G., Or, Reuven, S. Giebel, Matthias Stelljes, Passweg, J, Socie, G, M. Stelljes, M. Labopin, J. Finke, Canaani, Jonathan, Aljurf M., Socié, Gerard, Labopin, M, Sandra Eder, R. Or, Beohou E., Stelljes, Matthias, J. Canaani, D. Beelen, Myriam Labopin, Eder, Sandra, J. Passweg, Beelen, D, Arcese, William, Gunhan Gurman, Labopin, Myriam, A. Nagler, G. Gurman, M. Mohty, Gurman, G, Sanz, J, Mohty, M, Juergen Finke, Cortelezzi A., Gerard Socié, Canaani J., G. Socié, Giebel S., A. Cortelezzi, Nagler A., Arcese, W, Beohou, E, Mohty, Mohamad, Arcese W., Sanz J., Beelen, Dietrich, William Arcese, Giebel, S, Reuven Or, Arnon Nagler, Stelljes M., J. Sanz, Eder, S, Aljurf, Mahmoud, Giebel, Sebastian, E. Beohou, Cortelezzi, Agostino, Cortelezzi, A, W. Arcese, Eric Beohou, Nagler, A, Or R., Nagler, Arnon, Labopin M., Jakob Passweg, Finke J., Eder S., Mohamad Mohty, Dietrich Beelen, Aljurf, M, Jaime Sanz, Passweg, Jakob, M. Aljurf, Beelen D., Sebastian Giebel, Jonathan Canaani, Agostino Cortelezzi, Finke, Jürgen, Mahmoud Aljurf, S. Eder, Or, R, Mohty M., Stelljes, M, Passweg J., Finke, J, Beohou, Eric, Gurman, Gunhan, Socie G., Finke J, Socié G, Finke, Juergen, Nagler A, Beohou E, Gurman G, Sanz J, Or R, Cortelezzi A, Giebel S, Beelen D, Arcese W, Passweg J, Labopin M, Eder S, Mohty M, Canaani J, Stelljes M, Aljurf M   +108 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Comparison of Myeloablative Versus Reduced-Intensity Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia: A Cohort Study

Turkish Journal of Hematology, 2019
Objective: Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment modality for a variety of malignant and non-malignant hematologic disorders. Myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) regimens
Rafiye Çiftçiler, Hakan Göker, Haluk Demiroğlu, Elifcan Aladağ, Salih Aksu, İbrahim Calalettin Haznedaroğlu, Nilgün Sayınalp, Osman Özcebe, Fatma Tekin, Yahya Büyükaşık   +9 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Treosulfan Based Conditioning Regimen Is Associated with Better Overall Survival Compared to Busulfan Based Regimens in Older Children with Thalassaemia Major

, 2019
Treosulfan based conditioning regimens are increasingly being used in children with Thalassaemia major [TM] with improved outcomes {Mathews et al – BBMT ]. In India, children are generally referred late for a hematopoietic stem cell transplant [HSCT] and
Kulkarni, Uday, George, Biju, Lionel, Sharon, Lakshmi, Kavitha, Korula, Anu, Mathews, Vikram, Abubacker, Fouzia N., Abraham, Aby, Devasia, Anup J., Srivastava, Alok   +9 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source