Results 81 to 90 of about 434,913 (295)

Modeling Promising Nonmyeloablative Conditioning Regimens in Nonhuman Primates [PDF]

Human Gene Therapy, 2014
Minimal conditioning or even no conditioning would be the preferred preparation for most gene therapy applications for nonmalignant diseases. However, reduced intensity conditioning (RIC) regimens in patients with nonhematologic malignancies have not led to long-term engraftment unless a selective advantage was present for the transplanted donor cells.
Devikha, Chandrasekaran, Betty, Nakamoto, Korashon L, Watts, Hans-Peter, Kiem, Thalia, Papayannopoulou   +4 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Myeloablative vs reduced intensity T-cell–replete haploidentical transplantation for hematologic malignancy

Blood Advances, 2019
: In the absence of prospective studies that examine the effect of conditioning regimen intensity after T-cell–replete haploidentical transplant for acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and myelodysplastic syndrome (MDS), a ...
Scott R. Solomon, Andrew St. Martin, Nirav N. Shah, Giancarlo Fatobene, Monzr M. Al Malki, Karen K. Ballen, Asad Bashey, Nelli Bejanyan, Javier Bolaños Meade, Claudio G. Brunstein, Zachariah DeFilipp, Richard E. Champlin, Ephraim J. Fuchs, Mehdi Hamadani, Peiman Hematti, Christopher G. Kanakry, Joseph P. McGuirk, Ian K. McNiece, Stefan O. Ciurea, Marcelo C. Pasquini, Vanderson Rocha, Rizwan Romee, Sagar S. Patel, Sumithira Vasu, Edmund K. Waller, John R. Wingard, Mei-Jie Zhang, Mary Eapen   +27 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Outcome of CBV (Carmustine, Cyclophosphamide, Etoposide) Conditioning Regimen for Autologous Stem Cell Transplant in Lymphoma: A Retrospective Study from a Tertiary Cancer Center in South India

Indian Journal of Medical and Paediatric Oncology
Introduction In autologous stem cell transplant (ASCT) for lymphomas, no standard conditioning regimen has been defined so far. Thus, the choice is guided by the center's familiarity and experience with a particular regimen.
Narendran Krishnamoorthi, Bhanu Prakash, Dhanraju KM, Chinmaya Kumar Pani, Malliha Ram, Kalpana Rajesh, Biswajit Dubashi, Prasanth Ganesan, Smita Kayal   +8 more
doaj   +1 more source

Additional file 1: of Fludarabine-treosulfan compared to thiotepa-busulfan-fludarabine or FLAMSA as conditioning regimen for patients with primary refractory or relapsed acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT) [PDF]

, 2019
Table S1. Post-transplant cell therapy. Table S2. Drug doses in the three conditioning regimens (TBF, FT, FLAMSA). Table S3. Univariate analysis of ATG yes vs no stratified by conditioning regimen.
Matthias Eder (21135), Bochtler, Tilmann, Tilmann Bochtler, Bunjes, Donald, Dietrich Beelen (3449723), Savani, Bipin N., Donald Bunjes (3499079), Eder, Matthias, Brecht, Arne, Arne Brecht, Bipin Savani (2550130), Nagler, Arnon, Saraceni, Francesco, Nicolaus Kröger, Hélène Labussière-Wallet, Bochtler, Tilman, Dietger Niederwieser (467324), Mohamad Mohty, Dietrich Beelen, Kröger, Nicolaus, Myriam Labopin, Arnon Nagler (144514), Matthias Eder, Johanna Tischer (3449726), Labopin, Myriam, Dietger Niederwieser, Francesco Saraceni (3478556), Mohamad Mohty (2550127), Niederwieser, Dietger, Tilmann Bochtler (6636911), Francesco Saraceni, Donald Bunjes, Hermann Einsele, Labussière-Wallet, Hélène, Johanna Tischer, Bipin N. Savani, Arne Brecht (6636905), Hermann Einsele (38565), Tischer, Johanna, Myriam Labopin (2550118), Mohty, Mohamad, Hélène Labussière-Wallet (6636908), Nicolaus Kröger (229221), Beelen, Dietrich, Arnon Nagler, Einsele, Hermann   +45 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Experience with the Use of Thio/Mel Conditioning Regimen Prior to Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Клиническая онкогематология, 2019
Background. In multiple myeloma (MM) treatment a single autologous hematopoietic stem cell transplantation (auto-HSCT) is preceded by conditioning regimens aimed at intensifying cytoreductive effect.
S. V. Gritsaev, Ivan Ivanovich Kostroma, A. A. Zhernyakova, I. M. Zapreeva, E. V. Karyagina, Zh. V. Chubukina, S. A. Tiranova, I. S. Martynkevich, S. S. Bessmeltsev, A. V. Chechetkin   +9 more
doaj   +1 more source

Unrelated donor hematopoietic stem cell transplantation for patients with hematologic malignancies using a nonmyeloablative conditioning regimen of fludarabine, low-dose total body irradiation, and rabbit antithymocyte globulin

, 2004
Hematopoietic stem cell chimerism can be established after low-dose conditioning regimens, although the risk of donor cell rejection increases for unrelated donor transplantations. We added pretransplantation rabbit antithymocyte globulin (6 mg/kg) to an
Brecher, Barbara Adler, Kobbe, Kelly, Rowley, Scott D., Butrin, Linda, Pecora, Andrew L., Hsu, Jack S., McKiernan, Phyllis, Preti, Robert, Goldberg, Stuart L.   +8 more
core   +1 more source

Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies [PDF]

, 2009
The definitive version is available at www.blackwell-synergy.comWe here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies ...
Kamijo, Takehiko, Shiohara, Masaaki, Tanaka, Miyuki, Yanagisawa, Ryu, Nakazawa, Yozo, Sakashita, Kazuo, Koike, Kenichi, Shikama, Naoto   +7 more
core   +1 more source