Results 11 to 20 of about 57,130 (200)

Conducting the Needs Assessment #2: Using Needs Assessments in Extension Programming

EDIS, 2019
This second publication in the Conducting the Needs Assessment series provides Extension educators and other service providers with a foundational underpinning of how the needs assessment fits within the program planning process.
Matthew Benge, Laura Warner
doaj   +5 more sources

Creating a Successful Virtual Reality–Based Medical Simulation Environment: Tutorial

JMIR Medical Education, 2023
Innovation in medical education is not only inevitable but a requirement. Manikin-based simulation is currently the gold standard for supplemental clinical training; however, this modality requires significant equipment and personnel to ...
Sanchit Gupta, Kyle Wilcocks, Clyde Matava, Julian Wiegelmann, Lilia Kaustov, Fahad Alam   +5 more
doaj   +1 more source

Conducting the Needs Assessment #7: Phase 3 — Post-Assessment

EDIS
This is the seventh publication in the Conducting the Needs Assessment series. The post-assessment phase, also known as the utilization phase, of conducting a needs assessment includes setting priorities to make informed decisions, creating and ...
Matt Benge
doaj   +3 more sources

Improving Medication Adherence Through Adaptive Digital Interventions (iMedA) in Patients With Hypertension: Protocol for an Interrupted Time Series Study

JMIR Research Protocols, 2021
BackgroundThere is a strong need to improve medication adherence (MA) for individuals with hypertension in order to reduce long-term hospitalization costs. We believe this can be achieved through an artificial intelligence agent that helps the patient in
Etminani, Kobra, Göransson, Carina, Galozy, Alexander, Norell Pejner, Margaretha, Nowaczyk, Sławomir   +4 more
doaj   +1 more source

Investigating the Effects of Re-generated Urban Spaces on the Socio-Economic Performance of the Historical Context of Isfahan (Case study: Imam Ali Square) [PDF]

جغرافیا و برنامه‌ریزی محیطی, 2022
Extended Abstract:IntroductionImam Ali Square (AS) as the most important open space in the northern part of Isfahan with high activity density needs to achieve the desired quantitative and qualitative dimensions.
Hossein Jafari Jeblai, Seyed Mehdi Mousakazemi, hassan Hekmatnia, reza mokhtari   +3 more
doaj   +1 more source

Conducting the Needs Assessment #1: Introduction

EDIS, 2019
An integral step in the program development process is identifying the needs of a community. Educators seeking to develop and deliver an educational program must first be informed of what their audience lacks in order to develop the right curriculum or ...
Matthew Benge, Amy Harder, Laura Warner
doaj   +5 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source