Results 41 to 50 of about 133,001,789 (236)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Exploration of training needs assessment methodologies employed by ISO 9000 registered organizations [PDF]
, 1999 Plan BThe purpose of this study is to identify available methods or procedures for determining training needs and to determine which procedures would be appropriate for Northern Engraving Corporation given its culture and internal resources.
Johnson, Edsel J.
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Govanhill/Gorbals health needs assessment [PDF]
, 1995 The aim of this project was to assist the primary health care team carry out a comprehensive health needs assessment of practice populations and the existing clients of the nursing ...
Ross, Jan, McCulloch, Fiona
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Camden Childcare Needs Assessment [PDF]
, 2007 The Camden Childcare Needs Assessment is a mixed methods study that has sought to consider the childcare needs of parents in the borough, including considering where there is unmet demand, the adequacy of the timing of childcare provision and parental ...
Hoggart, L. +3 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: Inflammatory bowel diseases (IBD) are most often diagnosed in adolescence and young adulthood, affecting 10 in 100,000 pediatric patients in the US and Canada.
Jordyn Feingold +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Great Lakes Regional Pollution Prevention Roundtable (GLRPPR) Needs Assessment Study [PDF]
, 2014 The Survey Research Laboratory (SRL) at the University of Illinois assisted Principal Investigator Laura Barnes, Executive Director of the Great Lakes Regional Pollution Prevention Roundtable (GLRPPR), with a Web-based survey of GLRPPR members to ...
Anand, Sowmya
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