Results 51 to 60 of about 133,001,789 (236)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An assessment of climate vulnerability in the Middle San Pedro River [PDF]
, 2000 : As a major component of the Climate Assessment Project for the Southwest, this study is part of a larger effort to assess the vulnerability of natural and human systems to climate variability and change in the southwestern U.S.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2019 Supplemental material, Copies-of-Instruments_FINAL_1 for Conducting a health education needs assessment in rural Nicaragua by Johnathan D Steppe, Barbara J Blake, Mari-Amanda Dyal, Theresa S Bailey, Kandice J Porter and Jon Thompson in Health Education ...
Johnathan D Steppe (8187555) +5 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Kansas Infant-Toddler Services (Part C): Needs Assessment 2019 [PDF]
, 2019 This needs assessment is submitted to the Kansas Department of Health and Environment (KDHE) Bureau of Family Health which has contracted with the Center for Public Partnerships and Research at the University of Kansas (CPPR) to conduct an independent ...
Gillam, Rebecca +2 more
core +1 more source
Multi-Stack Persistent Scatterer Interferometry Analysis in Wider Athens, Greece
Remote Sensing, 2017 The wider Athens metropolitan area serves as an interesting setting for conducting geodetic studies. On the one hand, it has a complex regional geotectonic characteristic with several active and blind faults, one of which gave the deadly M w 5.9 ...
Ioannis Papoutsis +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Implementation Science, 2018 Background The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group.
Andrew Booth +10 more
doaj +1 more source