Results 61 to 70 of about 60,151 (200)
Developing and Piloting Suicide Prevention Training in Pediatric Primary Care
JAACAP OpenObjective: Suicide prevention is an expected competency of pediatric primary care clinicians (PPCCs). Suicide prevention training should be tailored to the recipient’s setting, localized needs, and available models of care. This article describes a first
John T. Parkhurst, PhD +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty
Scientific ReportsResults of many investigations and statistical data indicate that aircraft accidents are an iceberg phenomenon for understanding the gap among traffic management, operations, and aviation systems.
Hendri Saputra, Sutanto Soehodho
doaj +1 more source
Journal of Research in Education Sciences面對世界變革及教育系統之需求，本研究重新從認識論與方法論建立課程評鑑之基礎，並擴大視野，跨越邊界，透過朝向問題化的設計思考，規劃能喚起個體在群體中及對系統的覺知，反思課程實踐，建立具價值與意義之課程評鑑引導設計。本研究主要運用團體討論法，經過8次，每次1-2小時的團體討論，進行「意義驅動與展化的課程評鑑工作坊」之引導設計， 並以關鍵字分析和提問類型進行資料分析，再以參與工作坊學員之意見調查與備課文件作為語料分析之佐證。本研究發現包括：一、融入展化學習及U型理論之問題化的設計思考可生成課程新的理解；二 ...
陳美如 Mei-Ju Chen +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Salāmat-i kār-i Īrān, 2020 Background and Objectives: Lack of comprehensive theses databases in various fields can be a reason for research problems in every field. In Iran, I has been several decades that due to scientific and cultural developments of work, the necessity to train
elaheh amouzadeh, aram tirgar
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source