Results 111 to 120 of about 413,327 (305)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Vibrant Soundbridge and Bone Conduction Hearing Aid in Patients with Bilateral Malformation of External Ear

International Archives of Otorhinolaryngology, 2016
Introduction Hearing loss is the most common clinical finding in patients with malformation of the external ear canal. Among the possibilities of treatment, there is the adaptation of hearing aids by bone conduction and the adaptation of implantable ...
Maria Fernanda Capoani Garcia Mondelli, Thais Cristina Barbosa Mariano, Heitor Marques Honório, Rubens Vuono de Brito   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

eLife
The cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors TBX3 and TBX5 are required for CCS development and associated with overlapping and ...
Ozanna Burnicka-Turek, Katy A Trampel, Brigitte Laforest, Michael T Broman, Xinan H Yang, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek, Kaitlyn M Shen, Igor R Efimov, Ivan P Moskowitz   +12 more
doaj   +1 more source

Evaporation and condensation of spherical interstellar clouds. Self-consistent models with saturated heat conduction and cooling

, 2007
Shortened version: The fate of IS clouds embedded in a hot tenuous medium depends on whether the clouds suffer from evaporation or whether material condensates onto them.
Begelman, Brüns, Brüns, Böhringer, Campbell, Chevalier, Cowie, Crank, Dalgarno, Dalton, Danly, de Jong, de Jong, Field, G. Hensler, Graham, Heyer, Juncosa, Keenan, Khan, Koyama, Manheimer, Matte, McKee, McKee, Morse, Murray, Normandeau, Penston, Pietz, Raymond, Rozyczka, Samland, Slavin, Taylor, van Leer, Vieser, W. Vieser, Wakker, Wakker, Yorke   +40 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Model of the Frictional Heating of Inconel 718 and Titanium (ti-6al-4v) in Helium [PDF]

, 1991
A computer model of the frictional heating of metals in an inert environment has been developed. The model incorporates the effects of the heat loss from the samples due to conduction, radiation, and convection to the surroundings.
Skowlund, Christopher T.
core   +1 more source

Customised broadband metamaterial absorbers for arbitrary polarisation

, 2010
This paper shows that customised broadband absorption of electromagnetic waves having arbitrary polarisation is possible by use of lossy cut-wire (CW) metamaterials.
Burokur, Busch, Christos Christopoulos, Dolling, Fang, Govyadinov, Guo, Hiroki Wakatsuchi, Holloway, John Paul, Kern, Kordás, Lai, Luo, Pendry, Pendry, Service, Smith, Soukoulis, Stephen Greedy, Tao, Wen, Zhou, Zhou   +23 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The evolution of interstellar clouds in a streaming hot plasma including heat conduction

, 2007
To examine the evolution of giant molecular clouds in the stream of a hot plasma we performed two-dimensional hydrodynamical simulations that take full account of self-gravity, heating and cooling effects and heat conduction by electrons.
Balbus, Begelman, Blitz, Bonner, Braun, Braun, Brown, Brown, Brüns, Böhringer, Cowie, Crank, Dalgarno, Danly, de Jong, de Jong, Dinge, Ebert, Fahlman, Fall, Field, Freeman, G. Hensler, Hensler, Heyer, Juncosa, Keenan, Kerp, Kerp, Konz, Köppen, Malyshkin, Manheimer, Matsushita, Max, McKee, McKee, McKee, Morse, Murray, Murray, Pietz, Pietz, Quilis, Rozyczka, Samland, Slavin, Stil, Stone, Taylor, van Leer, Vietri, W. Vieser, Wakker, Wakker, Wolfire, Yorke   +56 more
core   +1 more source