Results 111 to 120 of about 415,480 (301)

The Alternate Arm Converter: A New Hybrid Multilevel Converter With DC-Fault Blocking Capability

, 2013
This paper explains the working principles, supported by simulation results, of a new converter topology intended for HVDC applications, called the alternate arm converter (AAC).
Critchley, R, Crookes, W, Green, TC, Hassan, F, Merlin, MMC, Mitcheson, PD, Trainer, DR   +6 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The evolution of interstellar clouds in a streaming hot plasma including heat conduction

, 2007
To examine the evolution of giant molecular clouds in the stream of a hot plasma we performed two-dimensional hydrodynamical simulations that take full account of self-gravity, heating and cooling effects and heat conduction by electrons.
Balbus, Begelman, Blitz, Bonner, Braun, Braun, Brown, Brown, Brüns, Böhringer, Cowie, Crank, Dalgarno, Danly, de Jong, de Jong, Dinge, Ebert, Fahlman, Fall, Field, Freeman, G. Hensler, Hensler, Heyer, Juncosa, Keenan, Kerp, Kerp, Konz, Köppen, Malyshkin, Manheimer, Matsushita, Max, McKee, McKee, McKee, Morse, Murray, Murray, Pietz, Pietz, Quilis, Rozyczka, Samland, Slavin, Stil, Stone, Taylor, van Leer, Vietri, W. Vieser, Wakker, Wakker, Wolfire, Yorke   +56 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Vibrant Soundbridge and Bone Conduction Hearing Aid in Patients with Bilateral Malformation of External Ear

International Archives of Otorhinolaryngology, 2016
Introduction Hearing loss is the most common clinical finding in patients with malformation of the external ear canal. Among the possibilities of treatment, there is the adaptation of hearing aids by bone conduction and the adaptation of implantable ...
Maria Fernanda Capoani Garcia Mondelli, Thais Cristina Barbosa Mariano, Heitor Marques Honório, Rubens Vuono de Brito   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Self-Organization of Reconnecting Plasmas to Marginal Collisionality in the Solar Corona

, 2012
We explore the suggestions by Uzdensky (2007) and Cassak et al. (2008) that coronal loops heated by magnetic reconnection should self-organize to a state of marginal collisionality.
Aly, Aschwanden, Bradshaw, Carmichael, Cassak, Doschek, E. G. Zweibel, Goodman, Hori, Imada, Imada, Imada, Kano, Klimchuk, Klimchuk, Mandrini, Ohyama, Pneuman, Reale, Reale, S. Imada, Sakamoto, Shimizu, Shimizu, Shimojo, Sonnerup, Spitzer, Sweet, Teriaca, Tsuneta, Uchida, Uzdensky, Vekstein, Warren, Warren, Yokoyama   +35 more
core   +1 more source

Permanent Magnet Biased Inductors: And Additional investigations on: Biasing topologies for AC applications, Parametric transformers using permanent magnets, and Optimization of conduction losses on planar transformer windings [PDF]

, 2023
Andres Revilla Aguilar
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source