Results 81 to 90 of about 774,398 (260)
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Confidence regions in nonlinear regression
, 2013 The aim of this thesis is a comprehensive description of the properties of a nonlinear least squares estimator for a nonlinear regression model with normally distributed errors and thorough development of various methods for constructing confidence ...
Marcinko, Tomáš
core
Hybrid confidence regions based on data depth
, 2012 We consider the general problem of constructing confidence regions for, possibly multi-dimensional, parameters when we have available more than one approach for the construction. These approaches may be motivated by different model assumptions, different
Lee, SMS
core +2 more sources
Scientific ReportsWe presented a method to find potential cancer attractors using single-cell RNA sequencing (scRNA-seq) data. We tested our method in a Glioblastoma Multiforme (GBM) dataset, an aggressive brain tumor presenting high heterogeneity.
Marcos Guilherme Vieira Junior +4 more
doaj +1 more source
BMC Genetics, 2012 Background The traditional strategy to map QTL is to use linkage analysis employing a limited number of markers. These analyses report wide QTL confidence intervals, making very difficult to identify the gene and polymorphisms underlying the QTL effects.
Fernández Ana I +9 more
doaj +1 more source
Globaltest confidence regions and their application to ridge regression. [PDF]
Biom J, 2021 Xu N, Solari A, Goeman J.
europepmc +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Multidimensional confidence regions for pareto, exponential, and normal distributions
, 2017 The two classical approaches in estimation theory are point estimation and confidence interval estimation. A confidence interval contains the unknown parameter of interest of a parametric family of distributions with a probability greater than or equal ...
Lennartz, Jens
core +1 more source
Distribution of Toxoplasma gondii among cattle in certain regions of Ukraine
Ukrainian Journal of Veterinary Sciences, 2022 Toxoplasma gondii is the agent of toxoplasmosis, which is common to both humans and cattle. That is why the goal of work was to study the spreading of the agent of toxoplasmosis among cattle in certain regions of Ukraine, which in turn will make it ...
Vladyslava Storozhuk +6 more
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