Results 81 to 90 of about 474,935 (329)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dirac operators on configuration spaces and Yang-Mills quantum field theory

Nuclear Physics B
In this paper we discuss a connection between Dirac operators on configuration spaces and Yang-Mills quantum field theory. We first show that the Hamilton operators of the self-dual and anti-self-dual sectors of a Yang-Mills quantum field theory emerge ...
Johannes Aastrup, Jesper Møller Grimstrup   +1 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A study on the spatial configuration and collective system of street space in Tsutsuishi fishing village in relation to the service wet spaces

Journal of Asian Architecture and Building Engineering
Questioning the research on traditional settlements and town planning, which tends to result in the mere recording and preservation of the appearance of houses, this study positions itself as an attempt to achieve a careful and more holistic ...
Shinji Terada, Satoshi Boda, Shin-Ya Nishimura   +2 more
doaj   +1 more source

Correlation between accessibility to urban open spaces and city livability: case of Abu Dhabi, UAE, and Biskra city, Algeria

Frontiers in Sustainable Cities
Open spaces, such as parks, plazas, and urban voids, play a crucial role in enhancing human well-being and significantly contribute to the overall quality of urban life.
Rim Meziani, Heba Al Sayyed, Hafnaoui Hamzaoui, Safia Mahfoud, Hadjira Sakhri, Dua'a Al-Rifai, Yassine Bada   +6 more
doaj   +1 more source

Design of a digital interactive configuration, flexible and inexpensive, for monitoring the movements of people in real time

SCIRES-IT, 2014
We aim to introduce here the idea and the first results of a still ongoing research regarding the setup of a flexible and inexpensive digital interactive configuration, which has the goal of tracking the position and routes of a certain amount of ...
Enrico Costa, Camillo Trevisan
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Spatial Logic of Privacy: Uncovering Privacy Patterns in Shared Housing Environments

Buildings
In response to the growing relevance of shared housing models such as co-living and co-housing, this study investigates how spatial configuration affects the experience and negotiation of privacy in shared domestic environments.
Ana Moreira, Francisco Serdoura
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

HOS: A Hybrid Metaheuristic One-Parameter-at-a-Time Strategy for T-Way Test Case Generation

IEEE Access
Interactions between software configuration parameters are a main source of system failures. However, the exponential growth of configuration spaces makes exhaustive testing impossible.
Muhammad Sabo Yahaya, Ahmad Sobri Hashim, Sani Tijjani, Jabir Abubakar Salisu, Fatima Sabo Usman, Garba Elhuseini   +5 more
doaj   +1 more source