Results 31 to 40 of about 119,841 (246)
Plasma heat load in the toroidal gaps of the ITER-like plasma facing units in WEST tokamak
Nuclear Materials and EnergyThe heat load deposited in the toroidal gaps between two tungsten monoblocks remains an open problem to prepare safe and powerful experiments in ITER.
Q. Tichit +12 more
doaj +1 more source
Journal of Advanced Ceramics, 2022 Hydrogen isotope permeation through structural materials is a key issue for developing nuclear fusion energy, which will cause fuel loss and radioactive pollution.
Liyu Zheng +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Nuclear Materials and EnergyThe estimation of the heat flux density distribution profiles in tokamak devices is a very important research topic for edge plasma physics purposes and also to ensure the safety of the machine.
Y. Anquetin +8 more
doaj +1 more source
Crossing the Boundaries, 2010 By superposition of regular gauge instantons or merons, ensembles of gauge fields are constructed which describe the confining phase of SU (2) Yang-Mills theory. Various properties of the Wilson loops, the gluon condensate and the topological susceptibility are found to be in qualitative agreement with phenomenology or results of lattice calculations.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
High Voltage, 2022 Needle electrodes are widely used in the research of corona discharge. Aiming at the problem of needle electrode discharge in a large‐scale space (tens or even hundreds of centimetres), a hybrid model was proposed in the previous work.
Dingchen Li +8 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source