Results 31 to 40 of about 707,405 (284)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Dividing and setting strategy of improving calculation efficiency for needle electrode corona discharge with a large‐scale space

open access: yesHigh Voltage, 2022
Needle electrodes are widely used in the research of corona discharge. Aiming at the problem of needle electrode discharge in a large‐scale space (tens or even hundreds of centimetres), a hybrid model was proposed in the previous work.
Dingchen Li   +8 more
doaj   +1 more source

Refining light impurity content estimates at the lower divertor based on experimental data in WEST

open access: yesNuclear Materials and Energy, 2023
WEST is an actively cooled, long-pulse tokamak with nearly all plasma-facing components (PFC) made of tungsten (W). One of the aims of WEST is to study plasma operation with W PFCs in preparation for long-pulse operation on W divertor devices like ITER ...
A. Grosjean   +7 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Confinement induced control of similarity solutions in premelting dynamics and other thin film problems

open access: yes, 2019
We study the combined effects of nonlocal elasticity and confinement induced ordering on the dynamics of thermomolecular pressure gradient driven premelted films bound by an elastic membrane.
Pramanik, Satyajit, Wettlaufer, John S.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

The effects of partial stable confinement on the voluntary activity of weanling thoroughbred foals : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science, Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2017
This thesis discusses an observational study, which evaluates the effects of partial stable confinement on the voluntary activity of weanling Thoroughbreds kept at pasture.
Lilly, Vanessa Maree
core  

Signals of confinement in Green functions of SU(2) Yang-Mills theory

open access: yes, 2004
The vortex picture of confinement is employed to explore the signals of confinement in Yang-Mills Green functions. By using SU(2) lattice gauge theory, it has been well established that the removal of the center vortices from the lattice configurations ...
A. Cucchieri   +13 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Experimental and numerical modeling of plasma start-up assisted by electron drift injection on J-TEXT

open access: yesNuclear Fusion, 2023
Start-up is one of the critical phases for tokamak discharge. The electron drift injection (EDI) system has been developed on J-TEXT for start-up studies.
Junli Zhang   +14 more
doaj   +1 more source

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