Results 41 to 50 of about 125,160 (219)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Infernal instabilities in negative-triangularity plasmas with negative central shear

Nuclear Fusion
A systematic numerical investigation is carried out to understand magnetohydrodynamic stability of the ideal infernal-kink instability in tokamak plasmas with both negative triangularity (neg-D) shaping and negative central shear for the equilibrium ...
X.M. Zhang, L. Li, Y.Q. Liu, Z.Y. Dong, J.W. Li, Y. Liang, F.C. Zhong   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Bifurcation from L-mode to internal transport barrier triggered by a magnetic island in tokamak plasmas

Nuclear Fusion
Magnetic islands are believed to be responsible for triggering the internal transport barrier (ITB) around the rational surface and hence improves confinement in magnetic confinement fusion plasma, for more than two decades.
Feiyue Mao, Nengchao Wang, Katsumi Ida, Chuanxu Zhao, Qinlin Tao, Yangbo Li, Zhengkang Ren, Zijian Xuan, Ruomu Wang, Jiangang Fang, Xixuan Chen, Haonan Fang, Hanhui Li, Song Zhou, Wei Yan, Zhoujun Yang, Donghui Xia, Zhongyong Chen, Lu Wang, Yonghua Ding, the J-TEXT Team   +20 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

High-beta disruption prediction study on HL-2A with instance-based transfer learning

Nuclear Fusion
Unmitigated disruptions pose a much more serious threat when large-scale tokamaks are operating in the high performance regime. Machine learning based disruption predictors can exhibit impressive performance.
Y. Zhong, W. Zheng, Z.Y. Chen, W. Yan, F. Xia, L.M. Yu, F.M. Xue, C.S. Shen, X.K. Ai, Z.Y. Yang, Y.L. Yu, Z.S. Nie, Y.H. Ding, Y.F. Liang, Z.P. Chen, J-TEXT Team   +15 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Recent advances in physics and applications of 3D magnetic fields on the J-TEXT tokamak

Nuclear Fusion
This paper summarizes recent experimental and theoretical progress achieved on the J-TEXT tokamak during the past two years, with an emphasis on the physics and applications of three-dimensional (3D) magnetic fields.
Nengchao Wang, Yonghua Ding, Zhongyong Chen, Donghui Xia, Zhoujun Yang, Zhipeng Chen, Wei Zheng, Wei Yan, Da Li, Song Zhou, Chengshuo Shen, Zhengkang Ren, Feiyue Mao, Yangbo Li, Xixuan Chen, Chuanxu Zhao, Qinghu Yang, Qinlin Tao, Chi Lei, Wentao Geng, Zhangsheng Huang, Hanhui Li, Jie Yang, Yutong Yang, Jiankun Hua, Zhangrong Hou, Wei Xie, Jiangang Fang, Shengyang Xiao, Yinlong Yu, Fanxi Liu, Keze Li, Hai Liu, Xin Xu, Peng Shi, Ting Long, Jinlong Guo, Fengming Xue, Xinkun Ai, Yu Zhong, Junli Zhang, Zhonghe Jiang, Li Gao, Xiaoqing Zhang, Bo Rao, Lu Wang, Weixin Guo, Shiyong Zeng, Ping Zhu, Minghai Liu, Tao Xu, Shaoxiang Ma, Yong Yang, Chuan Li, Zhijiang Wang, Ming Zhang, Kexun Yu, Xiwei Hu, Y. Liang, Q. Yu, K. W. Gentle, Yuan Pan, the J-TEXT Team   +62 more
doaj   +1 more source