Results 61 to 70 of about 736,721 (340)

Development of the WAter-interface Permeation In Tritium-exposed materIals (Wapiti) tritium experiment and preliminary Eurofer97 results

open access: yesNuclear Materials and Energy
The control of tritium inventory and permeation is crucial for the safe operation of fusion reactors. To measure these phenomena, a novel tritium experiment is introduced and used to measure tritium permeation through Eurofer97 at room temperature, with ...
F. Montupet-Leblond   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Supercooled confinement

open access: yesJournal of High Energy Physics
A bstract We study general properties of confinement phase transitions in the early universe. An observable gravitational wave signal from such transitions requires significant supercooling.
Agrawal, P   +3 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Understanding Color Confinement

open access: yes, 2013
Some aspects are discussed of the mechanism of color confinement in QCD by condensation of magnetic monopoles in the vacuum.Comment: Presented at the Conference Windows on the Universe, Quy Nhon (Vietnam) Aug.
Di Giacomo, Adriano
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Analytical treatment of bosonic d-wave scattering in isotropic harmonic waveguides

open access: yes, 2012
We analyze d-wave resonances in atom-atom scattering in the presence of harmonic confinement by employing a higher partial wave pseudopotential. Analytical results for the scattering amplitude and transmission are obtained and compared to corresponding ...
Giannakeas, P.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Self-organized dynamics and the transition to turbulence of confined active nematics

open access: yes, 2019
We study how confinement transforms the chaotic dynamics of bulk microtubule-based active nematics into regular spatiotemporal patterns. For weak confinements, multiple continuously nucleating and annihilating topological defects self-organize into ...
Aghvami, S. Ali   +6 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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