Results 61 to 70 of about 177,629 (318)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Infernal instabilities in negative-triangularity plasmas with negative central shear
Nuclear FusionA systematic numerical investigation is carried out to understand magnetohydrodynamic stability of the ideal infernal-kink instability in tokamak plasmas with both negative triangularity (neg-D) shaping and negative central shear for the equilibrium ...
X.M. Zhang +6 more
doaj +1 more source
Proceedings of the 14th ACM SIGPLAN conference on Object-oriented programming, systems, languages, and applications, 1999 Sharing and transfer of object references is difficult to control in object-oriented languages. Unconstrained sharing poses serious problems for writing secure components in object-oriented languages. In this paper, we present a set of inexpensive syntactic constraints that strengthen encapsulation in object-oriented programs and ...
Bokowski, Boris, Vitek, Jan
openaire +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
, 2000 12 pages, LaTeX file, 2 epsf figures. Contribution to the Proceedings of the workshop ``Lattice fermions and the structure of the vacuum'', 5-9 October 1999, Dubna ...
Kovács, T. G., Tomboulis, E. T.
openaire +2 more sources
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Discretionary capability confinement [PDF]
International Journal of Information Security, 2006 Motivated by the need of application-level access control in dynamically extensible systems, this work proposes a static annotation system for modeling capabilities in a Java-like programming language. Addressing a common critique of capability systems, the proposed annotation system can provably enforce capability confinement.
openaire +2 more sources
Confining the robber on cographs
Contributions to Discrete Mathematics, 2023 In a game of Cops and Robbers on graphs, usually the cops' objective is to capture the robber---a situation which the robber wants to avoid invariably. In this paper, we begin with introducing the notions of trapping and confining the robber and discussing their relations with capturing the robber.
openaire +3 more sources