Results 41 to 50 of about 707,405 (284)
Detection of confinement and jumps in single molecule membrane trajectories
, 2006 We propose a novel variant of the algorithm by Simson et al. [R. Simson, E.D. Sheets, K. Jacobson, Biophys. J. 69, 989 (1995)]. Their algorithm was developed to detect transient confinement zones in experimental single particle tracking trajectories of ...
J. Rudnick +5 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2013 We show that exotic phases arise in generalized lattice gauge theories known as quantum link models in which classical gauge fields are replaced by quantum operators.
Banerjee, D. +3 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Lonely Too Long: Redefining and Reforming Juvenile Solitary Confinement [PDF]
, 2016 Solitary confinement is a frequently used penal tool in all fifty states against all types of offenders. However, since its development in the 1800s, solitary confinement has been found to have damaging psychological effects.
Lee, Jessica
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Nuclear Materials and EnergyThe control of tritium inventory and permeation is crucial for the safe operation of fusion reactors. To measure these phenomena, a novel tritium experiment is introduced and used to measure tritium permeation through Eurofer97 at room temperature, with ...
F. Montupet-Leblond +6 more
doaj +1 more source
Understanding the spectrum during the tearing mode locking by rotating RMP in J-TEXT
AIP Advances, 2022 The rotating resonant magnetic perturbation (RMP) could lock the tearing mode (TM) and prevent disruption. It is found that the TM instantaneous frequency oscillates during TM locking on the RMP.
Da Li +18 more
doaj +1 more source
Long Range Magnetic Order and the Darwin Lagrangian
, 1999 We simulate a finite system of $N$ confined electrons with inclusion of the Darwin magnetic interaction in two- and three-dimensions. The lowest energy states are located using the steepest descent quenching adapted for velocity dependent potentials ...
A. Compagner +36 more
core +1 more source