Results 131 to 140 of about 131,723 (308)

3d numerical model of a confined fracture tests in concrete [PDF]

, 2013
The paper deals with the numerical simulation of a confined fracture test in concrete. The test is part of the experimental work carried out at ETSECCPB-UPC in order to elucidate the existence of a second mode of fracture under shear and high compression,
Carol, Ignacio, López Garello, Carlos María, Montenegro, O., Sfer, D.   +3 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Experimental and numerical studies on rock damage law in straight-hole cut blasting under biaxial confining pressure

International Journal of Mining Science and Technology
To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting, tests were performed under different confining pressures.
Xiantang Zhang, Zhaobin Li, Hui Yu, Hongmin Zhou, Hongli Wang, Xiangtuan Jiao, Fuzhi Wang   +6 more
doaj   +1 more source

Dissipated energy in undrained cyclic triaxial tests [PDF]

, 2015
Energy-based methods are an emerging tool for the evaluation of liquefaction potential. These methods relate excess pore water pressure build-up to seismic energy dissipated per unit volume.
Azeiteiro, RJN, Coelho, PALF, Grazina, JC, Taborda, DMG   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical study on the shear strength of granular materials under the low confining pressure

Soils and Foundations
The relationship between stress and strength in granular soil differs under low confining pressure as compared to high confining pressure, which is of great importance for the geotechnical engineering. Numerical simulations using discrete element method (
Daosheng Ling, Tiantian Hu, Jing Wang, Xiukai Wang, Changyu Shi, Yao Tang   +5 more
doaj   +1 more source

Cyclic confining pressure and rock permeability: Mechanical compaction or fines migration. [PDF]

Heliyon, 2023
Kozhevnikov EV, Turbakov MS, Riabokon EP, Gladkikh EA, Poplygin VV.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source