Results 111 to 120 of about 7,934,450 (360)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Perceptions of inequality and meritocracy: their interplay in shaping preferences for market justice in Chile (2016–2023)

open access: yesFrontiers in Sociology
IntroductionSeveral countries have experienced a shift toward the privatization and commodification of public goods, welfare policies, and social services.
Juan Carlos Castillo   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Community-Based Conservation for the Sustainable Management of Conservation Conflicts: Learning from Practitioners [PDF]

open access: gold, 2021
Juliette Young   +16 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Who is a Civilian in Gaza? Reflection on the Loss of Protection of Civilian Persons: An Interdisciplinary Treatise Focused on IHL with Military Strategy Aspects

open access: yesObrana a Strategie
The demand for significantly increased protection of civilians in the Gaza Strip from the consequences of Israeli military operations, together with reports of high civilian casualties, has resonated in public discourse for more than 18 months.
Veronika D´Evereux, Vojtěch Sedlák
doaj   +1 more source

Organizational Innovators: A Study of Workplace Intra-Employee Conflict Management Strategies [PDF]

open access: yes, 2017
[Excerpt] Whilst the issue of intra-employee conflict is clearly one that impacts today’s organization, it is less clear how this conflict is addressed and resolved in contemporary workplaces.
Hann, Deborah, Nash, David
core   +1 more source

Challenges in Modelling Social Conflicts: Grappling with Polysemy

open access: gold, 2011
M. Neumann   +4 more
openalex   +1 more source

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