Results 81 to 90 of about 145,556 (272)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Work-Family Conflict and Facilitation among Employees in Hong Kong
, 2014 Work-family imbalance can induce negative consequences, such as poor physical and psychological well-being for individuals. Hong Kong employees commonly agree that work-family balance is important for them, but it is difficult to balance work and family
Wong, Chi Kin
core
Apology Laws and the Doctor-Patient Relationship
Voices in Bioethics, 2014 In 2000, the Institute of Medicine (IOM) published “To Err Is Human: Building a Safer Health System,” a report on the woeful state of patient safety in American hospitals.1 This alarming study not only forced the medical establishment to acknowledge the ...
Lisa Kearns
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Doctor-nurse conflict is widespread in public hospitals posing a significant threat to the quality of healthcare delivery, compromising patient outcomes and undermining the fundamental purpose of the healthcare system. Effective management of this inter-professional conflict is imperative to prevent patients from bearing the brunt of this discord ...
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Discover Public HealthBackground Maternal health outcomes remain a pressing concern in fragile and conflict-affected settings such as Somalia, where financial and sociocultural barriers exacerbate disparities in access to essential health services.
Salad Halane +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interprofessional conflict between doctors and nurses remains a persistent challenge in healthcare systems globally, especially in resource-constrained settings like Nigeria. In Kogi State, systemic issues such as poor infrastructure, inadequate staffing, and role ambiguity have intensified doctor–nurse tensions, with adverse consequences for patient ...
Yunusa, Edime +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source