Results 101 to 110 of about 145,556 (272)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evolution of the Governmental Accounting Reform implementation in Greek Public Hospitals: Testing the institutional framework

Purpose – In an attempt to promote efficiency, effectiveness and economy in health service production, the Greek government imposed in 2003 an accrual basis financial and cost accounting system in all public hospitals of the National Health System (NHS).
Eriotis, Nikolaos, Stamatiadis, Filippos
core  

Re -inventing the "cry for help": attempted suicide in Britain in the mid-twentieth centuary c 1937-1969

, 2012
PhDAfter 1945 in Britain there emerges an ‘epidemic’ of ‘attempted suicide’ that is read as not aiming at death exclusively, but is instead a form of communication – a ‘cry for help’.
Millard, Christopher James
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Medical ethics decision-making in three hospitals: A look at dilemmas, decision-makers, and the practice of clinical ethics

, 2001
This dissertation is a study of medical ethics decision-making in three American hospitals. It presents the moral issues caregivers and clinical ethicists identify as struggles , and discusses the process of moral decision-making.
Kurtz, Kathleen Susan
core  

Development and evaluation of a de-escalation training intervention in adult acute and forensic units: the EDITION systematic review and feasibility trial

Health Technology Assessment
Background Containment (e.g. physical restraint and seclusion) is used frequently in mental health inpatient settings. Containment is associated with serious psychological and physical harms.
Owen Price, Cat Papastavrou Brooks, Isobel Johnston, Peter McPherson, Helena Goodman, Andrew Grundy, Lindsey Cree, Zahra Motala, Jade Robinson, Michael Doyle, Nicholas Stokes, Christopher J Armitage, Elizabeth Barley, Helen Brooks, Patrick Callaghan, Lesley-Anne Carter, Linda M Davies, Richard J Drake, Karina Lovell, Penny Bee   +19 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Embodying Conflict: Representations of Hospitals and Seas in Israeli Film after the Second Intifada

, 2020
In the years following the Second Intifada, Israeli cinema has centered on two prominent themes: “the mundane,” focusing on the civilian experience, mainly through the feminine body, and “the penitent soldier,” focusing on the masculine body in combat ...
Greenberg, Slava
core  

A health’s view on violence [PDF]

Revista Brasileira em Promoção da Saúde, 2012
Violence is the intentional use of physical strength or power, actually or under threat, against oneself, someone else, or against a group or community, which results or has a high probability of resulting in injury, death or psychological damage, bad ...
Paula Borges Jacques, Querubina Bringel Olinda   +1 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source