Results 91 to 100 of about 145,556 (272)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Industrial conflict in Britain [PDF]

open access: yes
The economic analysis of conflict in Britain has previously concentrated on examining aggregate strike frequency. The thesis recognises the limitations of this approach and argues for the investigation of a broader definition of conflict and at a ...
Dickerson, Andrew P.
core  

The city hospitals as control space in the state and capital

open access: yes, 2023
Bu çalışma kapsamında, Şehir Hastaneleri’nin büyüklüğü toplumsal yeniden üretim bağlamında hegemonya kavramıyla sorunsallaştırılmaktadır. Şehir Hastaneleri’nin mekânsal çelişkisine bakarak büyüklüğün bir değer ölçütü haline nasıl getirildiği yeniden ...
Tangün, Yağız Alp
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Professional power and the state: A study of five professions in state welfare agencies in the UK

open access: yes, 1988
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The thesis defines a profession as a group of workers who have been authorised by the state to determine aspects of their own work, training and ...
Ovretveit, John Arne
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Nurse and burnout of the role conflict and role effect of uncertainty in job satisfaction (Bayrampaşa State Hospital and Avicenna Private Hospital in İstanbul comparative example) [PDF]

open access: yes, 2015
Bu çalışmada, kamu ve özel hastane örnekleri kullanılarak hemşirelerin mesleki anlamda yaşadıkları rol çatışması ve rol belirsizliği düzeylerinin belirlenmesi neticesinde tükenmişlik ve iş doyumu olgularıyla ilişkileri araştırılmıştır.
Akdaş, Ezine
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Assessing Accrual Accounting Reform in Greek Public Hospitals: An Empirical Investigation

open access: yes
During the last decades, several countries worldwide have introduced financial management reforms, as an important part of the New Public Management (NPM) initiative at one or more levels of government sector, by either replacing or transforming their ...
Vasiliou, Dimitrios   +2 more
core  

Meal Interference with Antibiotics Administered Orally in Kentucky Hospitals

open access: yes, 1982
Hospitals within the State of Kentucky were surveyed to determine if the size of the hospitals influence the frequency of potential meal interference with the administration of oral antibiotics where the empty stomach concept must be fulfilled.
Harper, Shirley
core  

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