Results 201 to 210 of about 1,089,192 (256)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Impact of acetic acid chromoendoscopy on detection of serrated lesions in the proximal colon compared with white-light endoscopy. [PDF]

Endosc Int Open
Savóia de Oliveira FJ, Mota FL, Pereira Junior EMA, Loureiro JF, Navarro-Rodriguez T.   +4 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Stage-Specific Processing in Numerosity Working Memory: ERP Evidence for Load and Mismatch Effects in a Delayed Match-to-Sample Task. [PDF]

NeuroSci
Duan M, Liu Z, Sui L.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Contrast-enhanced endoscopic ultrasound-guided additional ethanol ablation after early detection of occult residual pancreatic insulinoma. [PDF]

Endoscopy
Sugiura R, Kuwatani M, Kawakubo K, Shiratori S, Oda S, Nakajima K, Sakamoto N.   +6 more
europepmc   +1 more source

Event-Based surveillance (EBS) implementation in unstable and conflict settings: lessons learned from Sudan. [PDF]

Confl Health
Malik EM, Yiu SM, Habibi M, Ismaiel IM, Ridwan AY, Izzoddeen A, Alzain MA, Osman MM, Daoud L, Gafar N, Himmat S, Bashier H, Sadek M, Raja MA.   +13 more
europepmc   +1 more source

Tiger Habitat Occupancy in Chitwan-Parsa Complex: Implications for Human-Tiger Conflict Management Strategies. [PDF]

Ecol Evol
Prasai A, Lamichhane S, Pathak A, Karki A, Rayamajhi T, Mintz J, Dahal BR, Dhakal BK, Pokheral CP, Subedi N, Bhattarai BP.   +10 more
europepmc   +1 more source

Coordinated Radio Emitter Detection Process Using Group of Unmanned Aerial Vehicles. [PDF]

Sensors (Basel)
Mazuro M, Skokowski P, Kelner JM.
europepmc   +1 more source